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PPRC1 is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants.
Gene Name: | peroxisome proliferator-activated receptor gamma, coactivator-related 1 |
Synonyms: | PPRC1, PGC-1-related coactivator, PGC-1 related co-activator, KIAA0595, PRC, RP11-302K17.6 |
Target Sequences: | AF325193 AAK11573.1 Q5VV67 |
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