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PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

PPP2R2B belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12.

Gene Name: protein phosphatase 2, regulatory subunit B, beta
Family/Subfamily: Protein Phosphatase Regulatory Subunit , not assigned-Protein Phosphatase Non Catalytic
Synonyms: PPP2R2B, B55BETA, PP2ABBETA, PP2APR55BETA, PP2A subunit B isoform beta, PR2AB55BETA, PR55-BETA, SCA12, Spinocerebellar ataxia 12, PP2A subunit B isoform R2-beta, PP2AB55BETA, PP2APR55B, PR55BETA, PR2ABBETA, PR2APR55BETA, PR52B
Target Sequences: NM_004576 NP_004567.1 Q00005

Publications (1)

1
EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. Yi Bao, Gokce Oguz, Wee Chyan Lee, Puay Leng Lee, Kakaly Ghosh, Jiayao Li, Panpan Wang, Peter E Lobie, Sidse Ehmsen, Henrik J Ditzel, Andrea Wong, Ern Yu Tan, Soo Chin Lee, Qiang Yu. Nature communications. 2020 November;11:5878. [Full Text Article] [PubMed:33208750] [PMC:PMC7674491] Related Antibodies: LS-C761012.

☰ Filters
Antibodies (21)
Proteins (15)
Over-Expression Lysate (11)
Primary (21)
Recombinant (4)
PPP2R2B (36)
Human (21)
Mouse (6)
Rat (5)
Bovine (1)
Monkey (1)
Pig (1)
IHC (2)
IHC-P (2)
WB (20)
Flo (1)
ELISA (15)
IF (3)
IP (4)
Peptide-ELISA (1)
rabbit (19)
mouse (2)
Product Group
IHCPlus (1)
IgG (16)
IgG2a,k (1)
IgG2b,k (1)
monoclonal mc (2)
polyclonal pc (19)
1B10 (1)
1F3 (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (13)
aa104-130 (7)
90-170 aa, Internal (1)
aa2-14 (1)
aa22-128 (1)
aa25-75 (1)
No (35)
Yes (1)
GST (2)
GST, N-terminus (2)
Myc-DDK (Flag) (11)
Human (12)
293T Cells (8)
HEK 293 Cells (3)
Wheat Germ Extract (4)
Purified (2)
PPP2R2B Antibody - Western blot analysis of PPP2R2B expression in rat brain (A), Hela (B), C6 (C), mouse brain (D) whole cell lysates.
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PPP2R2B Rabbit anti-Human Polyclonal Antibody
Mouse, Bovine, Rat, Pig, Human, Monkey
WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
PPP2R2B Antibody - Anti-PPP2R2B antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PPP2R2B Mouse anti-Human Monoclonal (aa22-128) (1F3) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
PPP2R2B Antibody - Western blot analysis of extracts of various cell lines, using PPP2R2B antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 5s.
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PPP2R2B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
PPP2R2B Rabbit anti-Human Polyclonal (aa25-75) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
PPP2R2B Antibody - Formalin-fixed and paraffin-embedded human brain tissue with PPP2R2B Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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PPP2R2B Rabbit anti-Human Polyclonal (aa104-130) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Select
PPP2R2B Rabbit anti-Human Polyclonal (aa2-14) Antibody
Human
WB
Unconjugated
100 µg/$466
Select
PPP2R2B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IP, WB
Unconjugated
100 µg/$331
PPP2R2B Antibody - IHC image of PPP2R2B Antibody diluted at 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
PPP2R2B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
PPP2R2B Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
PPP2R2B Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
PPP2R2B Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
PPP2R2B Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
Select
PPP2R2B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
PPP2R2B Rabbit anti-Human Polyclonal (aa104-130) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
PPP2R2B Rabbit anti-Human Polyclonal (aa104-130) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
PPP2R2B Rabbit anti-Human Polyclonal (aa104-130) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
PPP2R2B Rabbit anti-Human Polyclonal (aa104-130) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
PPP2R2B Rabbit anti-Human Polyclonal (aa104-130) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
PPP2R2B Rabbit anti-Human Polyclonal (aa104-130) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
PPP2R2B Rabbit anti-Human Polyclonal (90-170 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PPP2R2B Antibody - Immunoprecipitation of PPP2R2B transfected lysate using anti-PPP2R2B monoclonal antibody and Protein A Magnetic Bead.
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PPP2R2B Mouse anti-Human Monoclonal (1B10) Antibody
Human
ELISA, IP
Unconjugated
100 µg/$423
PPP2R2B Antibody - Western blot analysis of extracts from HeLa cells, using PPP2R2B antibody.
Select
PPP2R2B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
PPP2R2B Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PPP2R2B Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PPP2R2B Protein - 12.5% SDS-PAGE of human PPP2R2B stained with Coomassie Blue
Select
Wheat Germ Extract
GST
78.1 kDa
10 µg/$479; 25 µg/$670
PPP2R2B Protein - 12.5% SDS-PAGE of human PPP2R2B stained with Coomassie Blue
Select
Wheat Germ Extract
GST
74.25 kDa
10 µg/$479; 25 µg/$670
Viewing 1-25 of 36 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).