PPP1R9B / Spinophilin

protein phosphatase 1, regulatory subunit 9B

Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

PPP1R9B / Spinophilin (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human PPP1R9B / Spinophilin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88304

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.2 kDa

Price:

20 µg/$215

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PPP1R9B / Spinophilin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108708

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.2 kDa

Price:

100 µg/$710

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Human PPP1R9B / Spinophilin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70913

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.2 kDa

Price:

20 µg/$1,107

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Human PPP1R9B / Spinophilin Protein (Recombinant GST, N-terminus) (aa708-817) - LS-G63394

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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