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PPP1CC / PP1 Gamma

protein phosphatase 1, catalytic subunit, gamma isozyme

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E.

Gene Name: protein phosphatase 1, catalytic subunit, gamma isozyme
Family/Subfamily: Protein Phosphatase , PP1
Synonyms: PPP1CC, PPP1G, pp1 gamma 1, pp1c gamma, PP1gamma, PP-1G, PP1 gamma, pp1 gamma 2, Protein Phosphatase 1 gamma
Target Sequences: NM_002710 NP_002701.1 P36873

Publications (1)

1
HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1? in cervical malignancy. Seiki T, Nagasaka K, Kranjec C, Kawana K, Maeda D, Nakamura H, Taguchi A, Matsumoto Y, Arimoto T, Wada-Hiraike O, Oda K, Nakagawa S, Yano T, Fukayama M, Banks L, Osuga Y, Fujii T. BMC cancer. 2015 15:230. (WB; Human) [Full Text Article] [PubMed:25886518] [PMC:PMC4399203]

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
PPP1CC / PP1 Gamma (6)
No (6)
6His, N-terminus + 6His, C-terminus (2)
GST (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (2)
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E. coli
6His, N-terminus + 6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
40.2 kDa
10 µg/$344; 50 µg/$584
PPP1CC / PP1 Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
36.8 kDa
100 µg/$494
PPP1CC / PP1 Gamma Protein - 12.5% SDS-PAGE of human PPP1CC stained with Coomassie Blue
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Wheat Germ Extract
GST
61.27 kDa
10 µg/$479; 25 µg/$670
PPP1CC / PP1 Gamma Protein - Purified recombinant protein PPP1CC was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
36.8 kDa
20 µg/$1,107
PPP1CC / PP1 Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
36.8 kDa
20 µg/$150
Select
E. coli
6His, N-terminus + 6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
40.2kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).