PPM1D / WIP1

protein phosphatase, Mg2+/Mn2+ dependent, 1D

PPM1D / WIP1 is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

PPM1D / WIP1 (6)

Publications

No (6)

Tag

GST, N-terminus (2)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human PPM1D / WIP1 Protein (Recombinant GST, N-terminus) (Full Length) - LS-G31174

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

93.1 kDa

Price:

2 µg/$439

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Human PPM1D / WIP1 Protein (Recombinant His) (aa98-375) - LS-G3204

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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Human PPM1D / WIP1 Protein (Recombinant GST, N-terminus) (aa496-605) - LS-G60741

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PPM1D / WIP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68278

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66.5 kDa

Price:

20 µg/$1,107

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Human PPM1D / WIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81818

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66.5 kDa

Price:

20 µg/$150

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PPM1D / WIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117195

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66.5 kDa

Price:

100 µg/$494

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