PPM1A / PP2CA

protein phosphatase, Mg2+/Mn2+ dependent, 1A

PPM1A / PP2CA is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

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Products

Proteins (12)

Type

Over-Expression Lysate (4)

Recombinant (8)

Target

PPM1A / PP2CA (12)

Publications

No (12)

Tag

6His, C-terminus (2)

GST (1)

GST, N-terminus (1)

His (2)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (9)

Mouse (1)

Source

293T Cells (2)

E. coli (6)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (3)

Biologically Active

Biologically active (1)

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Human PPM1A / PP2CA Protein (Recombinant GST, N-terminus) (aa1-382) - LS-G56463

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human PPM1A / PP2CA Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68472

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.3 kDa

Price:

20 µg/$1,107

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Human PPM1A / PP2CA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82260

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.3 kDa

Price:

20 µg/$150

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Human PPM1A / PP2CA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82261

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.8 kDa

Price:

20 µg/$150

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Human PPM1A / PP2CA Protein (Recombinant GST) (Full Length) - LS-G29838

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.76 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PPM1A / PP2CA Protein (Recombinant His-T7) (aa2-382) - LS-G25877

Source:

E. coli

Tag:

His-T7

Molecular Weight:

46.0 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human PPM1A / PP2CA Protein (Recombinant 6His, C-terminus) (Gly2-Trp382) - LS-G38693

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

43.5kD

Price:

10 µg/$269; 50 µg/$372; 500 µg/$1,585; 1 mg/$2,157

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PPM1A / PP2CA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104800

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.8 kDa

Price:

100 µg/$494

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PPM1A / PP2CA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101704

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.3 kDa

Price:

100 µg/$494

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Human PPM1A / PP2CA Protein (Recombinant 6His, C-terminus) (Gly2-Trp382) - LS-G139326

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

43.5 kDa

Price:

10 µg/$358; 50 µg/$458

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Human PPM1A / PP2CA Protein (Recombinant His) - LS-G3520

Source:

E. coli

Tag:

His

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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Mouse PPM1A / PP2CA Protein (Recombinant His) (Met1-Trp382) - LS-G98236

Source:

E. coli

Tag:

His

Molecular Weight:

43.3 kDa

Price:

100 µg/$721

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