PPID / Cyclophilin D

peptidylprolyl isomerase D

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.

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Products

Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

PPID / Cyclophilin D (10)

Publications

No (10)

Tag

6His, N-terminus + 6His, C-terminus (2)

GST (1)

His (1)

His-T7 (3)

Myc-DDK (Flag) (3)

Species

Human (7)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (6)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (3)

Biologically Active

Biologically active (1)

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Rat PPID / Cyclophilin D Protein (Recombinant His-T7) (aa7-191) - LS-G13952

Source:

E. coli

Tag:

His-T7

Molecular Weight:

24.0 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Human PPID / Cyclophilin D Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64747

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.6 kDa

Price:

20 µg/$1,107

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Human PPID / Cyclophilin D Protein (Recombinant GST) (Full Length) - LS-G29839

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PPID / Cyclophilin D Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74054

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.6 kDa

Price:

20 µg/$150

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PPID / Cyclophilin D Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100445

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.6 kDa

Price:

100 µg/$494

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Human PPID / Cyclophilin D Protein (Recombinant His) - LS-G3388

Source:

E. coli

Tag:

His

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human PPID / Cyclophilin D Protein (Recombinant 6His, N-terminus + 6His, C-terminus) (Met1-Ala370) - LS-G139469

Source:

E. coli

Tag:

6His, N-terminus + 6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

43.9 kDa

Price:

10 µg/$368; 50 µg/$504

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Human PPID / Cyclophilin D Protein (Recombinant 6His, N-terminus + 6His, C-terminus) (Met1-Ala370) - LS-G39617

Source:

E. coli

Tag:

6His, N-terminus + 6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

43.9kD

Price:

10 µg/$281; 50 µg/$420; 500 µg/$1,585; 1 mg/$2,157

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Human PPID / Cyclophilin D Protein (Recombinant His-T7) (aa7-206) - LS-G13947

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.6 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Mouse PPID / Cyclophilin D Protein (Recombinant His-T7) (aa9-189) - LS-G13951

Source:

E. coli

Tag:

His-T7

Molecular Weight:

23.5 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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