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PPIB / Cyclophilin B

peptidylprolyl isomerase B (cyclophilin B)

PPIB / Cyclophilin B is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.

Gene Name: peptidylprolyl isomerase B (cyclophilin B)
Synonyms: PPIB, Cyclophilin B, CYP-S1, S-cyclophilin, Rotamase B, Cyclophilin-like protein, CYPB, OI9, PPIase B, SCYLP
Target Sequences: NM_000942 NP_000933.1 P23284

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).