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PPAT

phosphoribosyl pyrophosphate amidotransferase

The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region.

Gene Name:	phosphoribosyl pyrophosphate amidotransferase
Synonyms:	PPAT, Amidophosphoribosyltransferase, ATASE, GPAT, PRAT
Target Sequences:	NM_002703 NP_002694.3 Q06203

Publications (2)

Quantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis. Zhao H, Chiaro CR, Zhang L, Smith PB, Chan CY, Pedley AM, Pugh RJ, French JB, Patterson AD, Benkovic SJ. The Journal of biological chemistry. 2015 290:6705-13. (WB; Human) [Full Text Article] [PubMed:25605736] [PMC:PMC4358094]

Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation. Chunliang Liu, Giselle M Knudsen, Anthony M Pedley, Jingxuan He, Jared L Johnson, Tomer M Yaron, Lewis C Cantley, Stephen J Benkovic. Journal of proteome research. 2019 May;18:2078-2087. [Full Text Article] [PubMed:30964683] [PMC:PMC6499638] Related Antibodies: LS-B9407, LS-C80815.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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