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PPARD / PPAR Delta

peroxisome proliferator-activated receptor delta

PPARD / PPAR Delta is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.

Gene Name: peroxisome proliferator-activated receptor delta
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: PPARD, FAAR, NUCI, PPAR-beta, PPAR-delta, NR1C2, NUC1, NUCII, Nuclear hormone receptor 1, PPARB, PPAR Delta
Target Sequences: NM_006238 NP_006229.1 Q03181

Publications (2)

1
Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus. Chen H, Li J, Li H, Hu Y, Tevebaugh W, Yamamoto M, Que J, Chen X. PloS one. 2012 7:e36504. (IHC-P; Mouse) [Full Text Article] [PubMed:22567161] [PMC:PMC3342176] Related Antibodies: LS-B45.
2
The PPARd Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos. Muhammad Idrees, Lianguang Xu, Marwa El Sheikh, Tabinda Sidrat, Seok-Hwan Song, Myeong-Don Joo, Kyeong-Lim Lee, Il-Keun Kong. International journal of molecular sciences. 2019 Dec;20:6066. [Full Text Article] [PubMed:31810173] [PMC:PMC6928732] Related Antibodies: LS-C437498.

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Antibodies (82)
Primary (82)
PPARD / PPAR Delta (82)
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monoclonal mc (11)
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aa260-426 (19)
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aa1-244 (4)
aa144-193 (4)
aa169-218 (4)
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No (80)
Yes (2)
PPARD / PPAR Delta Antibody - Anti-PPAR Delta antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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PPARD / PPAR Delta Goat anti-Human Polyclonal (aa430-441) Antibody
Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
PPARD / PPAR Delta Antibody - Anti-PPAR Delta antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal (aa39-54) Antibody
Dog, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
1 Each/$485
PPARD / PPAR Delta Antibody - LN18 Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
PPARD / PPAR Delta Antibody - LN18 Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
FITC Conjugated
100 µl/$442
PPARD / PPAR Delta Antibody - Immunofluorescence analysis of U20S cells.
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PPARD / PPAR Delta Antibody - 1:100 staining mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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PPARD / PPAR Delta Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
PPARD / PPAR Delta Antibody - Immunohistochemical staining of paraffin-embedded Human adult brain tissue within the normal limits using anti-PPARD mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120 oC for 3 min. (1:150)
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PPARD / PPAR Delta Mouse anti-Human Monoclonal (aa1-244) (OTI4D10) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
PPARD / PPAR Delta Antibody - Immunohistochemical staining of paraffin-embedded Human adult brain tissue within the normal limits using anti-PPARD mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120 oC for 3 min. (1:150)
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PPARD / PPAR Delta Mouse anti-Human Monoclonal (aa1-244) (Carrier-free) (OTI4D10) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal (aa367-394) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal (aa367-394) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal (aa367-394) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal (aa367-394) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal (aa367-394) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal (aa367-394) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
PPARD / PPAR Delta Antibody - Immunohistochemical analysis of human-liver tissue. Anti-PPAR Delta at 1:200 (4°C, overnight). Antigen retrieval - Sodium Citrate pH6 (>98°C, 20min). Secondary - 1:200 (room temp, 30min). Negative control - Secondary only
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PPARD / PPAR Delta Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
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PPARD / PPAR Delta Mouse anti-Human Monoclonal (5F4) Antibody
Mouse, Rat, Human
IF, IHC-P
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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PPARD / PPAR Delta Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$448
PPARD / PPAR Delta Antibody - PPARD monoclonal antibody (M01), clone 4E3-1B11 Western Blot analysis of PPARD expression in Jurkat.
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PPARD / PPAR Delta Mouse anti-Human Monoclonal (4E3-1B11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
PPARD / PPAR Delta Antibody - PPARD Antibody western blot of HepG2 cell line lysates (35 ug/lane). The PPARD antibody detected the PPARD protein (arrow).
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal (aa367-394) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal (aa364-393) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
PPARD / PPAR Delta Antibody - Western blot analysis of Mouse heart tissue, using PPARD Polyclonal Antibody at dilution of 1:500.
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PPARD / PPAR Delta Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).