POT1

protection of telomeres 1

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

POT1 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

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Human (3)

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293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human POT1 Protein (Recombinant GST, N-terminus) (aa1-95) - LS-G62109

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human POT1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70999

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.3 kDa

Price:

20 µg/$1,107

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Human POT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88518

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.3 kDa

Price:

20 µg/$150

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POT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101319

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.3 kDa

Price:

100 µg/$494

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