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PON3

paraoxonase 3

PON3 is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.

Gene Name: paraoxonase 3
Synonyms: PON3, Paraoxonase 3, Paraoxanase-3, Serum paraoxonase/lactonase 3
Target Sequences: L48516 AAC41996.1 Q15166

Publications (1)

1
Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice. Sarah L Kempster, Gusztav Belteki, Diana Licence, D Stephen Charnock-Jones, Gordon C S Smith. The Breast : official journal of the European Society of Mastology. 2012 Jan;302:E103-7. [Full Text Article] [PubMed:21952037] Related Antibodies: LS-C38071.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
PON3 (6)
No (6)
GST (1)
His (1)
His, N-Terminal (1)
His,N-terminus (1)
Myc-DDK (Flag) (2)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Insect Cells (1)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (1)
PON3 Protein - Active Paraoxonase 3 (PON3) by WB
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E. coli
His, N-Terminal
43kDa
10 µg/$377; 50 µg/$942; 200 µg/$1,600; 100 µg/$1,367; 1 mg/$3,009; 500 µg/$2,423; 5 mg/$6,581; 2 mg/$3,511
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Insect Cells
His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42 kDa
100 µg/$843
PON3 Protein - Recombinant Paraoxonase 3 By SDS-PAGE
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E. coli
His
43.2 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
PON3 Protein - 12.5% SDS-PAGE of human PON3 stained with Coomassie Blue
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Wheat Germ Extract
GST
66 kDa
2 µg/$439
PON3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.4 kDa
20 µg/$150
PON3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.4 kDa
100 µg/$494
Viewing 1-6 of 6 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).