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POMC / Proopiomelanocortin

proopiomelanocortin

POMC / Proopiomelanocortin is a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Gene Name: proopiomelanocortin
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: POMC, Alpha-MSH, ACTH, Adrenocorticotropin, Adrenocorticotropic hormone, Beta-LPH, CLIP, Gamma-MSH, Lipotropin gamma, LPH, Melanotropin alpha, Met-enkephalin, Melanotropin beta, NPP, Pro-ACTH-endorphin, Lipotropin beta, Melanotropin gamma, MSH, Proopiomelanocortin, Beta-endorphin, Beta-MSH, Gamma-LPH, POC, Pro-opiomelanocortin
Target Sequences: NM_000939 NP_000930.1 P01189

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Antibodies (82)
Primary (82)
POMC / Proopiomelanocortin (82)
Human (62)
Mouse (16)
Rat (15)
Monkey (1)
Pig (1)
IHC (11)
IHC-P (13)
WB (62)
DB (1)
ELISA (31)
IF (2)
IHC-Fx (2)
Peptide-ELISA (1)
SDS-PAGE (2)
rabbit (60)
mouse (21)
goat (1)
Product Group
IHCPlus (3)
PathPlus Cancer (1)
PathPlus Cancer Pathology (1)
IgG (31)
IgG1 (13)
IgG1,k (4)
IgG2a (3)
monoclonal mc (17)
polyclonal pc (59)
recombinant monoclonal rmc (6)
3E11 (1)
5D3A10 (1)
6D2B5 (1)
6Y8 (57) (2)
CLIP/2040R (2)
OTI1A8 (2)
OTI1B9 (2)
OTI1F3 (2)
OTI2B2 (2)
OTI4G4 (2)
r57 (2)
rCLIP/1407 (2)
APC (3)
APC Conjugated (3)
Azide-free (3)
Biotin Conjugated (11)
Carrier-free (8)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (4)
PE Conjugated (3)
Preservative Free (15)
Rhodamine Conjugated (1)
Unconjugated (51)
aa27-235 (16)
aa23-267 (8)
N-Terminus (2)
aa1-24 (2)
aa25-39 (2)
aa138-176 (1)
aa256-267 (1)
aa27-52 (1)
pSer168 (1)
No (82)
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POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µg/$231; 100 µg/$293; 200 µg/$324; 500 µg/$442
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POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal (Preservative Free) (Biotin) Antibody
Human
ELISA
Biotin Conjugated, Preservative Free
50 µg/$333
POMC / Proopiomelanocortin Antibody - IHC of paraffin-embedded Human breast tissue using anti-POMC mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (OTI2B2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$409
POMC / Proopiomelanocortin Antibody - IHC of paraffin-embedded Human breast tissue using anti-POMC mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (Carrier-free) (OTI2B2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$473
POMC / Proopiomelanocortin Antibody - Western blot analysis of extracts of various cells.
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POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
POMC / Proopiomelanocortin Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer using POMC Polyclonal Antibody at dilution of 1:30.
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POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$242; 60 µl/$284; 120 µl/$343; 200 µl/$451
POMC / Proopiomelanocortin Antibody - Western blot analysis of A172 cell, using POMC Polyclonal Antibody at dilution of 1:350.
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POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
20 µl/$242; 60 µl/$278; 120 µl/$338; 200 µl/$440
POMC / Proopiomelanocortin Antibody - Western blot of POMC / Proopiomelanocortin antibody.
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POMC / Proopiomelanocortin Rabbit anti-Mouse Polyclonal (aa27-235) Antibody
Mouse
WB
Unconjugated
100 µl/$297; 200 µl/$338; 500 µl/$475; 1 ml/$543
POMC / Proopiomelanocortin Antibody - Western blot of POMC / Proopiomelanocortin antibody.
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POMC / Proopiomelanocortin Rabbit anti-Mouse Polyclonal (aa27-235) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$304; 200 µl/$351; 500 µl/$502; 1 ml/$580
POMC / Proopiomelanocortin Antibody - Western blot of POMC / Proopiomelanocortin antibody.
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POMC / Proopiomelanocortin Rabbit anti-Mouse Polyclonal (aa27-235) (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$390; 200 µl/$475; 500 µl/$816; 1 ml/$889
POMC / Proopiomelanocortin Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY POMC (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-POMC.
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POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (Carrier-free) (OTI1A8) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$473
POMC / Proopiomelanocortin Antibody - Immunohistochemistry of paraffin-embedded Human brain using POMC Polyclonal Antibody at dilution of 1:30.
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POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$242; 60 µl/$284; 120 µl/$343; 200 µl/$451
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POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (6D2B5) Antibody
Human
ELISA, IF, WB
Unconjugated
0.1 mg/$426
POMC / Proopiomelanocortin Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-POMC mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (OTI1F3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$409
POMC / Proopiomelanocortin Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-POMC mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (Carrier-free) (OTI1F3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$473
POMC / Proopiomelanocortin Antibody - Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
POMC / Proopiomelanocortin Mouse anti-Human Recombinant Monoclonal (N-Terminus) (r57) Antibody
Human
ELISA, IHC-P
Unconjugated
100 µg/$495
POMC / Proopiomelanocortin Antibody - Goat Anti-Proopiomelanocortin / POMC Antibody (2µg/ml) staining of paraffin embedded Human Pituitary Gland. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
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POMC / Proopiomelanocortin Goat anti-Human Polyclonal (aa256-267) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µg/$455
POMC / Proopiomelanocortin Antibody - Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE) HIER using 10 mM sodium citrate buffer pH 6.0
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Fast Shipping
POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
POMC / Proopiomelanocortin Antibody - Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE) HIER using 10 mM sodium citrate buffer pH 6.0
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Fast Shipping
POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
POMC / Proopiomelanocortin Antibody - Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE) HIER using 10 mM sodium citrate buffer pH 6.0
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Fast Shipping
POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
POMC / Proopiomelanocortin Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY POMC (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-POMC.
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POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (Carrier-free) (OTI4G4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$473
POMC / Proopiomelanocortin Antibody - Immunohistochemistry - Anti-ACTH Picoband Antibody
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POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal (aa138-176) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
100 µg/$421
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POMC / Proopiomelanocortin Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$614
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POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (5D3A10) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$426
POMC / Proopiomelanocortin Antibody - Western Blot analysis of POMC expression in transfected 293T cell line by POMC monoclonal antibody (M01), clone 3E11.Lane 1: POMC transfected lysate(29.4 KDa).Lane 2: Non-transfected lysate.
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POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (3E11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$413
Viewing 1-25 of 82 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).