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POLR3E / SIN

polymerase (RNA) III (DNA directed) polypeptide E (80kD)

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene Name: polymerase (RNA) III (DNA directed) polypeptide E (80kD)
Synonyms: POLR3E, KIAA1452, RNA polymerase III subunit C5, RPC5, SIN
Target Sequences: NM_018119 NP_060589.1 Q9NVU0

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Products
Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
POLR3E / SIN (4)
No (4)
GST (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
POLR3E / SIN Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
79.7 kDa
20 µg/$215
POLR3E / SIN Protein - Purified recombinant protein POLR3E was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
79.7 kDa
20 µg/$1,107
POLR3E / SIN Protein - 12.5% SDS-PAGE of human POLR3E stained with Coomassie Blue
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Wheat Germ Extract
GST
99 kDa
10 µg/$479; 25 µg/$670
POLR3E / SIN Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
79.7 kDa
100 µg/$710
Viewing 1-4 of 4 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).