POLR3A

polymerase (RNA) III (DNA directed) polypeptide A, 155kDa

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

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Products

Antibodies (18)

Type

Primary (18)

Target

POLR3A (18)

Reactivity

Human (18)

Mouse (9)

Rat (4)

Bovine (1)

Chicken (1)

Chimpanzee (3)

Dog (4)

Gibbon (3)

Horse (3)

Monkey (5)

Pig (1)

Rabbit (4)

Zebrafish (1)

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Application

IHC (7)

IHC-P (2)

WB (14)

ChrIP (4)

ELISA (7)

ICC (1)

IF (1)

Peptide-ELISA (3)

Host

rabbit (18)

Isotype

IgG (12)

Clonality

polyclonal pc (18)

Format

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

Unconjugated (12)

Epitope

C-Terminus (4)

aa392-632 (4)

1-80 aa, N-terminal (1)

N-Terminus (1)

Pro68 (1)

aa1-200 (1)

aa182-482 (1)

aa19-68 (1)

aa31-80 (1)

Publications

No (18)

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POLR3A Antibody (1-80 aa, N-terminal) LS-C385581

Antibody:

POLR3A Rabbit anti-Human Polyclonal (1-80 aa, N-terminal) Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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POLR3A Antibody (aa182-482) LS-C185773

Antibody:

POLR3A Rabbit anti-Human Polyclonal (aa182-482) Antibody

Reactivity:

Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µl/$450

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POLR3A Antibody (aa31-80) LS-C119917

Antibody:

POLR3A Rabbit anti-Human Polyclonal (aa31-80) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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POLR3A Antibody (aa19-68) LS-C200611

Antibody:

POLR3A Rabbit anti-Human Polyclonal (aa19-68) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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POLR3A Antibody LS-C497445

Antibody:

POLR3A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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POLR3A Antibody (aa392-632) LS-C370117

Antibody:

POLR3A Rabbit anti-Human Polyclonal (aa392-632) Antibody

Reactivity:

Human

Applications:

ChrIP, ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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POLR3A Antibody (aa392-632, HRP) LS-C370119

Antibody:

POLR3A Rabbit anti-Human Polyclonal (aa392-632) (HRP) Antibody

Reactivity:

Human

Applications:

ChrIP, ELISA, IHC

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

POLR3A Antibody (aa392-632, Biotin) LS-C370126

Antibody:

POLR3A Rabbit anti-Human Polyclonal (aa392-632) (Biotin) Antibody

Reactivity:

Human

Applications:

ChrIP, ELISA, IHC

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

POLR3A Antibody (aa392-632, FITC) LS-C370125

Antibody:

POLR3A Rabbit anti-Human Polyclonal (aa392-632) (FITC) Antibody

Reactivity:

Human

Applications:

ChrIP, ELISA, IHC

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

POLR3A Antibody LS-C805016

Antibody:

POLR3A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

POLR3A Antibody (Pro68) LS-C177450

Antibody:

POLR3A Rabbit anti-Human Polyclonal (Pro68) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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POLR3A Antibody (N-Terminus) LS-C368898

Antibody:

POLR3A Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Chicken, Zebrafish, Pig, Rabbit, Mouse, Dog, Bovine, Rat, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

Select

POLR3A Antibody (aa1-200) LS-C753017

Antibody:

POLR3A Rabbit anti-Human Polyclonal (aa1-200) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

POLR3A Antibody LS-C824042

Antibody:

POLR3A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

POLR3A Antibody (C-Terminus) LS-C111186

Antibody:

POLR3A Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

POLR3A Antibody (C-Terminus, HRP) LS-C451048

Antibody:

POLR3A Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Dog, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

POLR3A Antibody (C-Terminus, Biotin) LS-C451531

Antibody:

POLR3A Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Dog, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

POLR3A Antibody (C-Terminus, FITC) LS-C451047

Antibody:

POLR3A Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Dog, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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