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POLR2M
polymerase (RNA) II (DNA directed) polypeptide M
Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.
| Gene Name: | polymerase (RNA) II (DNA directed) polypeptide M |
| Family/Subfamily: | Ion Channel , Glutamate receptor - ionotropic (NMDA receptor) |
| Synonyms: | POLR2M, Gdown1, GRINL1A, N-methyl D-aspartate-like 1A, Protein GRINL1A, isoforms 4/5, Gdown, Protein GRINL1A |
| Target Sequences: | AF326773 AAK92284.2 P0CAP2 |
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