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POLH / DNA Polymerase Eta
polymerase (DNA directed), eta
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.
| Gene Name: | polymerase (DNA directed), eta |
| Synonyms: | POLH, Polymerase (DNA directed), eta, RAD30, RAD30A, DNA polymerase eta, RAD30 homolog A, XP-V, XPV |
| Target Sequences: | NM_006502 NP_006493.1 Q9Y253 |
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