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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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POLG2
polymerase (DNA directed), gamma 2, accessory subunit
POLG2 is the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.
| Gene Name: | polymerase (DNA directed), gamma 2, accessory subunit |
| Synonyms: | POLG2, MTPOLB, PEOA4, POLG-BETA, POLGB, HP55, p55 |
| Target Sequences: | NM_007215 NP_009146.2 Q9UHN1 |
Publications (2)
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