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POLG

polymerase (DNA directed), gamma

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Gene Name: polymerase (DNA directed), gamma
Synonyms: POLG, DNA polymerase gamma, MIRAS, MTDPS4A, PEO, POLG1, POLGA, SANDO, PolG, catalytic subunit, PolG-alpha, SCAE, DNA polymerase subunit gamma-1, MTDPS4B
Target Sequences: NM_002693 NP_002684.1 P54098

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Products
Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
POLG (6)
No (6)
GST, N-terminus (1)
His-S (1)
Myc-DDK (Flag) (4)
Human (4)
293T Cells (2)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
POLG Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
POLG Protein - Recombinant  Polymerase DNA Directed Gamma 1 By SDS-PAGE
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E. coli
His-S
26.4 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
POLG Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
139.4 kDa
100 µg/$710
POLG Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
139.4 kDa
20 µg/$215
POLG Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
139.6 kDa
20 µg/$150
POLG Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
139.6 kDa
100 µg/$494
Viewing 1-6 of 6 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).