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POLE3 / DNA Polymerase Epsilon

polymerase (DNA directed), epsilon 3, accessory subunit

Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.

Gene Name:	polymerase (DNA directed), epsilon 3, accessory subunit
Synonyms:	POLE3, CHRAC17, CHRAC-17, Histone fold protein CHRAC17, HuCHRAC17, p17, YBL1, Arsenic transactivated protein, Arsenic-transactivated protein, AsTP, CHARAC17, DNA polymerase II subunit 3
Target Sequences:	NM_017443 NP_059139.3 Q9NRF9

Publications (8)

Further characterization of HeLa DNA polymerase epsilon. Chui G, Linn S. The Journal of biological chemistry. 1995 270:7799-808. (WB; Mouse) [PubMed:7536191]

Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. Li Y, Asahara H, Patel VS, Zhou S, Linn S. The Journal of biological chemistry. 1997 272:32337-44. [PubMed:9405441]

DNA synthesis on discontinuous templates by human DNA polymerases: implications for non-homologous DNA recombination. Islas L, Fairley CF, Morgan WF. Nucleic acids research. 1998 26:3729-38. [PubMed:9685489] [PMC:PMC147762]

Incorporation and excision of 9-(2-phosphonylmethoxyethyl)guanine (PMEG) by DNA polymerase delta and epsilon in vitro. Kramata P, Downey KM, Paborsky LR. The Journal of biological chemistry. 1998 273:21966-71. [PubMed:9705337]

Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. Li Y, Pursell ZF, Linn S. The Journal of biological chemistry. 2000 275:23247-52. [PubMed:10801849]

MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon. Vlatkovic N, Guerrera S, Li Y, Linn S, Haines DS, Boyd MT. Nucleic acids research. 2000 28:3581-6. [PubMed:10982879] [PMC:PMC110721]

Proteolysis of the human DNA polymerase epsilon catalytic subunit by caspase-3 and calpain specifically during apoptosis. Liu W, Linn S. Nucleic acids research. 2000 28:4180-8. [PubMed:11058115] [PMC:PMC113151]

Stimulation of human DNA polymerase epsilon by MDM2. Asahara H, Li Y, Fuss J, Haines DS, Vlatkovic N, Boyd MT, Linn S. Nucleic acids research. 2003 31:2451-9. [PubMed:12711691] [PMC:PMC154228]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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