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POLE3 / DNA Polymerase Epsilon

polymerase (DNA directed), epsilon 3, accessory subunit

Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.

Gene Name: polymerase (DNA directed), epsilon 3, accessory subunit
Synonyms: POLE3, CHRAC17, CHRAC-17, Histone fold protein CHRAC17, HuCHRAC17, p17, YBL1, Arsenic transactivated protein, Arsenic-transactivated protein, AsTP, CHARAC17, DNA polymerase II subunit 3
Target Sequences: NM_017443 NP_059139.3 Q9NRF9

Publications (8)

1
Further characterization of HeLa DNA polymerase epsilon. Chui G, Linn S. The Journal of biological chemistry. 1995 270:7799-808. (WB; Mouse) [PubMed:7536191]
2
Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. Li Y, Asahara H, Patel VS, Zhou S, Linn S. The Journal of biological chemistry. 1997 272:32337-44. [PubMed:9405441]
3
DNA synthesis on discontinuous templates by human DNA polymerases: implications for non-homologous DNA recombination. Islas L, Fairley CF, Morgan WF. Nucleic acids research. 1998 26:3729-38. [PubMed:9685489] [PMC:PMC147762]
4
Incorporation and excision of 9-(2-phosphonylmethoxyethyl)guanine (PMEG) by DNA polymerase delta and epsilon in vitro. Kramata P, Downey KM, Paborsky LR. The Journal of biological chemistry. 1998 273:21966-71. [PubMed:9705337]
5
Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. Li Y, Pursell ZF, Linn S. The Journal of biological chemistry. 2000 275:23247-52. [PubMed:10801849]
6
MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon. Vlatkovic N, Guerrera S, Li Y, Linn S, Haines DS, Boyd MT. Nucleic acids research. 2000 28:3581-6. [PubMed:10982879] [PMC:PMC110721]
7
Proteolysis of the human DNA polymerase epsilon catalytic subunit by caspase-3 and calpain specifically during apoptosis. Liu W, Linn S. Nucleic acids research. 2000 28:4180-8. [PubMed:11058115] [PMC:PMC113151]
8
Stimulation of human DNA polymerase epsilon by MDM2. Asahara H, Li Y, Fuss J, Haines DS, Vlatkovic N, Boyd MT, Linn S. Nucleic acids research. 2003 31:2451-9. [PubMed:12711691] [PMC:PMC154228]
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Antibodies (19)
Primary (19)
POLE3 / DNA Polymerase Epsilon (19)
Human (18)
Mouse (15)
Rat (10)
Bat (6)
Bovine (9)
Chicken (6)
Chimpanzee (9)
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Monkey (9)
Mustelid (1)
Orangutan (9)
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Xenopus (3)
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IHC (4)
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ELISA (1)
ICC (1)
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rabbit (18)
mouse (1)
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monoclonal mc (1)
polyclonal pc (18)
3C5.1 (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
Unconjugated (10)
N-Terminus (8)
C-Terminus (4)
aa97-147 (2)
aa5-34 (1)
No (19)
POLE3 / DNA Polymerase Epsilon Antibody - Immunofluorescence analysis of U2OS cells.
Select
POLE3 / DNA Polymerase Epsilon Antibody LS-C335676
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539
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POLE3 / DNA Polymerase Epsilon Antibody LS-C754135
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
POLE3 / DNA Polymerase Epsilon Antibody - Immunofluorescent analysis of CHRAC17 staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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POLE3 / DNA Polymerase Epsilon Antibody LS-C482624
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
POLE3 / DNA Polymerase Epsilon Antibody - Detection of Human and Mouse PolE3/p17 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-PolE3/p17 used at a dilution of 1:5000 (0.2 ug/ml). Detection: DAB.
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POLE3 / DNA Polymerase Epsilon Antibody (aa97-147) LS-C288056
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal (aa97-147) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
POLE3 / DNA Polymerase Epsilon Antibody - POLE3 Antibody western blot of K562 cell line lysates (35 ug/lane). The POLE3 antibody detected the POLE3 protein (arrow).
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POLE3 / DNA Polymerase Epsilon Antibody (aa5-34) LS-C100903
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal (aa5-34) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
POLE3 / DNA Polymerase Epsilon Antibody - SDS-polyacrylamide gel analysis of HeLa DNA pol purified by Mono S FPLC. The Mono S fraction of HeLa DNA pol (0.1 mg) was electrophoresed on a 7% SDS-polyacrylamide gel and stained with silver. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLE3 / DNA Polymerase Epsilon Antibody (clone 3C5.1) LS-C2650
POLE3 / DNA Polymerase Epsilon Mouse anti-Human Monoclonal (3C5.1) Antibody
Mouse, Mustelid, Human, Primate
IP, WB
Unconjugated
0.1 mg/$386
POLE3 / DNA Polymerase Epsilon Antibody - Detection of Human PolD3/p66 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-PolE3/p17 used at a dilution of 1:100.
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POLE3 / DNA Polymerase Epsilon Antibody (aa97-147) LS-C286497
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal (aa97-147) Antibody
Mouse, Human
IHC
Unconjugated
1 µg/$295; 100 µl/$532
POLE3 / DNA Polymerase Epsilon Antibody - POLE3 antibody Western blot of Mouse Liver lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLE3 / DNA Polymerase Epsilon Antibody (C-Terminus) LS-C146393
POLE3 / DNA Polymerase Epsilon Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
WB
Unconjugated
100 µl/$424
POLE3 / DNA Polymerase Epsilon Antibody - POLE3 antibody Western blot of Mouse Liver lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLE3 / DNA Polymerase Epsilon Antibody (C-Terminus, HRP) LS-C428952
POLE3 / DNA Polymerase Epsilon Rabbit anti-Mouse Polyclonal (C-Terminus) (HRP) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$469
POLE3 / DNA Polymerase Epsilon Antibody - POLE3 antibody Western blot of Mouse Liver lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLE3 / DNA Polymerase Epsilon Antibody (C-Terminus, Biotin) LS-C428950
POLE3 / DNA Polymerase Epsilon Rabbit anti-Mouse Polyclonal (C-Terminus) (Biotin) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
POLE3 / DNA Polymerase Epsilon Antibody - POLE3 antibody Western blot of Mouse Liver lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLE3 / DNA Polymerase Epsilon Antibody (C-Terminus, FITC) LS-C428951
POLE3 / DNA Polymerase Epsilon Rabbit anti-Mouse Polyclonal (C-Terminus) (FITC) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
POLE3 / DNA Polymerase Epsilon Antibody - Daudi Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLE3 / DNA Polymerase Epsilon Antibody (N-Terminus) LS-C30573
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
POLE3 / DNA Polymerase Epsilon Antibody - Daudi Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
POLE3 / DNA Polymerase Epsilon Antibody (N-Terminus, HRP) LS-C428955
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
WB
HRP Conjugated
100 µl/$442
POLE3 / DNA Polymerase Epsilon Antibody - Daudi Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
POLE3 / DNA Polymerase Epsilon Antibody (N-Terminus, Biotin) LS-C428953
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
WB
Biotin Conjugated
100 µl/$442
POLE3 / DNA Polymerase Epsilon Antibody - Daudi Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
POLE3 / DNA Polymerase Epsilon Antibody (N-Terminus, FITC) LS-C428954
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
WB
FITC Conjugated
100 µl/$442
POLE3 / DNA Polymerase Epsilon Antibody - POLE3 antibody Western blot of Fetal Lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
POLE3 / DNA Polymerase Epsilon Antibody (N-Terminus) LS-C102743
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
POLE3 / DNA Polymerase Epsilon Antibody - POLE3 antibody Western blot of Fetal Lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
POLE3 / DNA Polymerase Epsilon Antibody (N-Terminus, HRP) LS-C464517
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Chicken, Zebrafish, Rat, Hamster, Pig, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Orangutan, Chimpanzee
WB
HRP Conjugated
100 µl/$469
POLE3 / DNA Polymerase Epsilon Antibody - POLE3 antibody Western blot of Fetal Lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
POLE3 / DNA Polymerase Epsilon Antibody (N-Terminus, Biotin) LS-C464515
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Chicken, Zebrafish, Rat, Hamster, Pig, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Orangutan, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
POLE3 / DNA Polymerase Epsilon Antibody - POLE3 antibody Western blot of Fetal Lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
POLE3 / DNA Polymerase Epsilon Antibody (N-Terminus, FITC) LS-C464516
POLE3 / DNA Polymerase Epsilon Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Chicken, Zebrafish, Rat, Hamster, Pig, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Orangutan, Chimpanzee
WB
FITC Conjugated
100 µl/$469
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