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POLB / DNA Polymerase Beta

polymerase (DNA directed), beta

Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

Gene Name:	polymerase (DNA directed), beta
Synonyms:	POLB, DNA pol beta, Mutant DNA polymerase beta, DNA polymerase beta, DNA polymerase beta subunit
Target Sequences:	NM_002690 NP_002681.1 P06746

Publications (2)

Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice. Sobol RW, Foley JF, Nyska A, Davidson MG, Wilson SH. DNA repair. 2003 2:609-22. [PubMed:12713817] Related Antibodies: LS-C153861.

DNA polymerase beta-dependent long patch base excision repair in living cells. Asagoshi K, Liu Y, Masaoka A, Lan L, Prasad R, Horton JK, Brown AR, Wang XH, Bdour HM, Sobol RW, Taylor JS, Yasui A, Wilson SH. DNA repair. 2010 9:109-19. [PubMed:20006562] [PMC:PMC2819632] Related Antibodies: LS-C153861.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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