POLA1 / DNA Polymerase Alpha 1

polymerase (DNA directed), alpha 1, catalytic subunit

Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes.

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Proteins (3)

Type

Recombinant (3)

Target

POLA1 / DNA Polymerase Alpha 1 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

His, N-Terminal (1)

His-T7 (1)

Species

Human (2)

Mouse (1)

Source

E. coli (2)

Wheat Germ Extract (1)

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Human POLA1 / DNA Polymerase Alpha 1 Protein (Recombinant His, N-Terminal) (aa1240-1462) - LS-G25047

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

29.5 kDa

Price:

10 µg/$279; 50 µg/$432; 200 µg/$862; 1 mg/$1,962; 5 mg/$3,011; 2 mg/$2,148

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Human POLA1 / DNA Polymerase Alpha 1 Protein (Recombinant GST, N-terminus) (aa1363-1462) - LS-G59658

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse POLA1 / DNA Polymerase Alpha 1 Protein (Recombinant His-T7) (aa1209-1465) - LS-G25048

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.5 kDa

Price:

10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136

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