PNPT1

polyribonucleotide nucleotidyltransferase 1

RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.

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Proteins (4)

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Over-Expression Lysate (2)

Recombinant (2)

Target

PNPT1 (4)

Publications

No (4)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Purified (2)

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Human PNPT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83034

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86 kDa

Price:

20 µg/$150

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Human PNPT1 Protein (Recombinant GST) (Full Length) - LS-G35934

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

112.3 kDa

Price:

2 µg/$439

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PNPT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108414

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86 kDa

Price:

100 µg/$494

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Human PNPT1 Protein (Recombinant His) - LS-G3237

Source:

E. coli

Tag:

His

Price:

20 µg/$361; 100 µg/$739; 4 µg/$261

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