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PMP22

peripheral myelin protein 22

PMP22 is a major component of myelin expressed in the compact portion of essentially all myelinated fibers in the peripheral nervous system and is produced predominantly by Schwann cells. Studies in injured nerve suggested a role during Schwann cell growth and differentiation. PMP22 is expressed in cranial nerves but not in the mature central nervous system. Studies suggest a possible role of the PMP22 gene in the development of neoplasia in patients with neurofibromatosis and in the myelin degenerative Charcot-Marie-Tooth disease linked to chromosome 17p.

Gene Name: peripheral myelin protein 22
Synonyms: PMP22, CMT1E, DSS, GAS-3, GAS3, Growth arrest-specific 3, HMSNIA, PMP-22, CMT1A, HNPP, Peripheral myelin protein 22
Target Sequences: NM_000304 NP_000295.1 Q01453

Publications (2)

1
Characterization of a monoclonal antibody specific for human peripheral myelin protein 22 and its use in immunohistochemical studies of the fetal and adult nervous system. Gregson NA, Zhang G, Pritchard J, Wang A, Sanvito L, Hayday AC, Hughes RA. Journal of the peripheral nervous system : JPNS. 2007 12:10-Feb. (IHC) [PubMed:17374097]
2
Pmp22 super-enhancer deletion causes tomacula formation and conduction block in peripheral nerves. Harrison Pantera, Bo Hu, Daniel Moiseev, Chris Dunham, Jibraan Rashid, John J Moran, Kathleen Krentz, C Dustin Rubinstein, Seongsik Won, Jun Li, John Svaren. Human molecular genetics. 2020 June;29:1689-1699. [Full Text Article] [PubMed:32356557] [PMC:PMC7322568] Related Antibodies: LS-C383645.

☰ Filters
Products
Proteins (13)
Over-Expression Lysate (7)
Recombinant (6)
PMP22 (13)
No (13)
10His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (9)
Human (9)
Rat (1)
293T Cells (4)
E. coli (2)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Purified (2)
PMP22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
17.7 kDa
100 µg/$494
PMP22 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus
23.4 kDa
100 µg/$1,801; 20 µg/$1,247
PMP22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
17.7 kDa
100 µg/$494
PMP22 Protein - 12.5% SDS-PAGE of human PMP22 stained with Coomassie Blue
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Wheat Germ Extract
GST
44.3 kDa
2 µg/$439
PMP22 Protein - Purified recombinant protein PMP22 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
17.7 kDa
20 µg/$1,107
PMP22 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PMP22 Protein - Purified recombinant protein PMP22 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
17.7 kDa
20 µg/$1,107
PMP22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
17.7 kDa
20 µg/$150
PMP22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
17.7 kDa
20 µg/$150
PMP22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
17.7 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
17.7 kDa
20 µg/$150
PMP22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
17.7 kDa
100 µg/$494
PMP22 Protein - Recombinant Peripheral Myelin Protein 22 By SDS-PAGE
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E. coli
His-T7
21.7 kDa
10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
Viewing 1-13 of 13 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).