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PMAIP1 / NOXA
phorbol-12-myristate-13-acetate-induced protein 1
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 By similarity. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
| Gene Name: | phorbol-12-myristate-13-acetate-induced protein 1 |
| Family/Subfamily: | Apoptosis , not assigned-Other |
| Synonyms: | PMAIP1, NOXA, PMA-induced protein 1, Protein Noxa, APR |
| Target Sequences: | NM_021127 NP_066950.1 Q13794 |
Publications (1)
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