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PLS3 / T Plastin
plastin 3
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.
| Gene Name: | plastin 3 |
| Synonyms: | PLS3, T plastin, T-plastin, T fimbrin, Plastin 3, Plastin-3, Plastin 3 (T isoform) |
| Target Sequences: | NM_005032 NP_005023.2 P13797 |
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