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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PLK3

polo-like kinase 3

Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.

Gene Name: polo-like kinase 3
Family/Subfamily: Protein Kinase , Polo
Synonyms: PLK3, CNK, FNK, Polo-like kinase 3, PRK, Proliferation-related kinase, Cytokine-inducible kinase, FGF-inducible kinase, PLK-3
Target Sequences: NM_004073 NP_004064.2 Q9H4B4

Filtered by: None
Target
PLK3 (35)
Reactivity
Human (35)
Mouse (29)
Rat (13)
Bat (4)
Bovine (4)
Dog (4)
Gibbon (3)
Horse (4)
Monkey (4)
Pig (4)
Application
IHC (6)
IHC-P (3)
WB (32)
Flo (15)
ELISA (22)
IF (1)
Peptide-ELISA (3)
Host
rabbit (33)
goat (2)
Isotype
IgG (26)
Clonality
polyclonal pc (35)
Format
AP Conjugated (2)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (20)
Epitope
aa33-61 (8)
aa615-646 (8)
aa385-434 (4)
200-280 aa, Internal (1)
aa221-270 (1)
aa231-280 (1)
aa320-333 (1)
aa320-520 (1)
Publications
No (35)
Showing 1-25 of 35 results

IHC-plus™ PLK3 Antibody (aa320-333) LS-B10518
Goat Polyclonal to Human PLK3
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-PRK / PLK3 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Huma Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)

PLK3 Antibody LS-C401367
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl 0.3mg/ml  $205.00; 60µl 0.3mg/ml  $235.00; 120µl 0.3mg/ml  $295.00; 200µl 0.3mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human colon cancer using PLK3 Polyclonal Antibody at dilution of 1:30.

PLK3 Antibody (aa385-434) LS-C135264
Rabbit Polyclonal to Mouse PLK3
Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $365.00
PLK3 antibody Western blot of Mouse Brain lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

PLK3 Antibody LS-C676276
Rabbit Polyclonal (IgG) to Human PLK3
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl  $235.00; 100µl  $285.00
Immunohistochemistry of paraffin-embedded human colon cancer at dilution 1:100
Immunohistochemistry of paraffin-embedded human testis tissue at dilution 1:100

PLK3 Antibody LS-C805384
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunofluorescence Image
Western blot Image

PLK3 Antibody (aa33-61) LS-C324112
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
Unconjugated
200µl  $590.00

PLK3 Antibody (aa33-61, Biotin) LS-C216853
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
Biotin Conjugated
200µl  $740.00

PLK3 Antibody (aa33-61, FITC) LS-C216854
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
FITC Conjugated
200µl  $740.00

PLK3 Antibody (aa33-61, AP) LS-C216851
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
AP Conjugated
200µl  $740.00

PLK3 Antibody (aa33-61, APC) LS-C216852
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
APC Conjugated
200µl  $740.00

PLK3 Antibody (aa33-61, Azide-free, HRP) LS-C216855
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200µl  $740.00

PLK3 Antibody (aa33-61, PE) LS-C216857
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
PE Conjugated
200µl  $740.00

PLK3 Antibody LS-C753195
Rabbit Polyclonal (IgG) to Human PLK3
Human
ELISA, IHC, WB
Unconjugated
100µg  $335.00

PLK3 Antibody (aa33-61) LS-C164540
Rabbit Polyclonal to Mouse PLK3
Mouse, Human
Flo, WB
Unconjugated
400µl  $325.00
Mouse Plk3 Antibody western blot of WiDr cell line lysates (35 ug/lane). The Plk3 antibody detected the Plk3 protein (arrow).
Mouse Plk3 Antibody western blot of mouse Neuro-2a cell line lysates (35 ug/lane). The Plk3 antibody detected the Plk3 protein (arrow).

PLK3 Antibody (aa615-646) LS-C324110
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
Unconjugated
200µl  $590.00

PLK3 Antibody (aa615-646, Biotin) LS-C216847
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
Biotin Conjugated
200µl  $740.00

PLK3 Antibody (aa615-646, FITC) LS-C216848
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
FITC Conjugated
200µl  $740.00

PLK3 Antibody (aa615-646, APC) LS-C216846
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
APC Conjugated
200µl  $740.00

PLK3 Antibody (aa615-646, PE) LS-C216850
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
PE Conjugated
200µl  $740.00

PLK3 Antibody (aa615-646, AP) LS-C216845
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
AP Conjugated
200µl  $740.00

PLK3 Antibody (aa615-646, Azide-free, HRP) LS-C216849
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200µl  $740.00

PLK3 Antibody LS-C676279
Rabbit Polyclonal (IgG) to Human PLK3
Human
ELISA, IHC, IHC-P
Unconjugated
50µl  $235.00; 100µl  $285.00
Immunohistochemistry of paraffin-embedded human colon cancer at dilution 1:100
Immunohistochemistry of paraffin-embedded human testis tissue at dilution 1:100

PLK3 Antibody LS-C404647
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl 0.7mg/ml  $205.00; 60µl 0.7mg/ml  $235.00; 120µl 0.7mg/ml  $295.00; 200µl 0.7mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human cervical cancer using PLK3 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of paraffin-embedded Human cervical cancer using PLK3 Polyclonal Antibody at dilution of 1:40.

PLK3 Antibody (200-280 aa, Internal) LS-C383512
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Rat, Human
ELISA, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Fnk antibody

PLK3 Antibody (aa320-520) LS-C38289
Goat Polyclonal (IgG) to Human PLK3
Human
ELISA, WB
Unconjugated
100µg  $770.00
Showing 1-25 of 35 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).