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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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PLK3

polo-like kinase 3

Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.

Gene Name: polo-like kinase 3
Family/Subfamily: Protein Kinase , Polo
Synonyms: PLK3, CNK, FNK, Polo-like kinase 3, PRK, Proliferation-related kinase, Cytokine-inducible kinase, FGF-inducible kinase, PLK-3
Target Sequences: NM_004073 NP_004064.2 Q9H4B4


PLK3 Antibody - Anti-PRK / PLK3 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal to Human PLK3
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
PLK3 Antibody - PLK3 antibody Western blot of Mouse Brain lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Mouse PLK3
Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
PLK3 Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using PLK3 Polyclonal Antibody at dilution of 1:30.
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Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl   0.2mg/ml   $205.00; 60µl   0.2mg/ml   $235.00; 120µl   0.2mg/ml   $295.00; 200µl   0.2mg/ml   $395.00
PLK3 Antibody - Western blot of Fnk antibody
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Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Rat, Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
PLK3 Antibody - Western blot analysis of lysates from HepG2 cells, using PLK3 Antibody. The lane on the right is blocked with the synthesized peptide.
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Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
PLK3 Antibody - Western blot analysis of the lysates from RAW264.7cells using PLK3 antibody.
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Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
PLK3 Antibody - Immunohistochemistry of paraffin-embedded human colon cancer at dilution 1:100
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Rabbit Polyclonal (IgG) to Human PLK3
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $235.00; 100µl   $285.00
PLK3 Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Mouse PLK3
Mouse, Human
ELISA, Flo, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PLK3
Human
ELISA, IHC, WB
Unconjugated
100µg   $335.00
PLK3 Antibody - Mouse Plk3 Antibody western blot of WiDr cell line lysates (35 ug/lane). The Plk3 antibody detected the Plk3 protein (arrow).
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Rabbit Polyclonal to Mouse PLK3
Mouse, Human
Flo, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PLK3
Mouse, Human
ELISA, Flo, WB
APC Conjugated
200µl   $740.00
PLK3 Antibody - Immunohistochemistry of paraffin-embedded human colon cancer at dilution 1:100
Select
Rabbit Polyclonal (IgG) to Human PLK3
Human
ELISA, IHC, IHC-P
Unconjugated
50µl   $235.00; 100µl   $285.00
Viewing 1-25 of 36 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).