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PLEKHF1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.
| Gene Name: | pleckstrin homology domain containing, family F (with FYVE domain) member 1 |
| Synonyms: | PLEKHF1, APPD, LAPF, Phafin 1, Phafin-1, PHAFIN1, ZFYVE15, Apoptosis-inducing protein, Apoptosis-inducing protein D |
| Target Sequences: | NM_024310 NP_077286.3 Q96S99 |
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