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Unfortunately, the antibody (ID:37767) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



PLEC / Plectin

plectin

Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or "plectin 1, intermediate filament binding 500kDa". These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used.

Gene Name: plectin
Synonyms: PLEC, EBSO, LGMD2Q, HD1, PCN, PLEC1b, Plectin, PLTN, Plectin1, EBS1, PLEC1, Plectin-1
Target Sequences: NM_000445 NP_000436.2 Q15149
Featured Image

Featured PLEC / Plectin Antibody

LS-B8172 is a rabbit monoclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.


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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
PLEC / Plectin Rabbit IgG Monoclonal E398P Unconjugated Human, Mouse, Rat IHC-P, WB, IP C-Terminus No Primary
Anti-PLEC / Plectin Antibody (C-Terminus, clone E398P) IHC-plus™ LS-B8172
Immunohistochemistry Image
Western blot Image
Rabbit Monoclonal [clone E398P] (IgG) to Human PLEC / Plectin
Human, Mouse, Rat
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
PLEC / Plectin Rabbit IgG Polyclonal FITC Conjugated Human IHC-P, IHC-Fr, ICC, WB, ELISA aa175-400 No Primary
Anti-PLEC / Plectin Antibody (aa175-400, FITC) LS-C422623
Rabbit Polyclonal (IgG) to Human PLEC / Plectin
Human
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
FITC Conjugated
PLEC / Plectin Rabbit IgG Polyclonal Biotin Conjugated Human IHC-P, IHC-Fr, ICC, WB, ELISA aa175-400 No Primary
Anti-PLEC / Plectin Antibody (aa175-400, Biotin) LS-C422621
Rabbit Polyclonal (IgG) to Human PLEC / Plectin
Human
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
Biotin Conjugated
PLEC / Plectin Mouse IgG1 Monoclonal Unconjugated Human, Mouse, Rat IHC-P, IHC-Fr, WB No Primary
Anti-PLEC / Plectin Antibody LS-C124382
Mouse Monoclonal (IgG1) to Human PLEC / Plectin
Human, Mouse, Rat
IHC - Paraffin, IHC - Frozen, Western blot
Unconjugated
PLEC / Plectin Guinea pig IgG Polyclonal Unconjugated Human, Mouse, Bovine, Xenopus IHC-P, IHC-Fr, WB aa4367-4684 No Primary
Anti-PLEC / Plectin Antibody (aa4367-4684) LS-C38258
Guinea pig Polyclonal (IgG) to Human PLEC / Plectin
Human, Mouse, Bovine, Xenopus
IHC - Paraffin, IHC - Frozen, Western blot
Unconjugated
PLEC / Plectin Guinea pig IgG Polyclonal Unconjugated Human, Xenopus IHC-P, IHC-Fr, WB aa4367-4684 No Primary
Anti-PLEC / Plectin Antibody (aa4367-4684) LS-C38257
Guinea pig Polyclonal (IgG) to Human PLEC / Plectin
Human, Xenopus
IHC - Paraffin, IHC - Frozen, Western blot
Unconjugated
PLEC / Plectin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat, Guinea pig, Hamster IHC-P, WB aa2644-2671 No Primary
Anti-PLEC / Plectin Antibody (aa2644-2671) LS-C407651
Immunohistochemistry Image
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human PLEC / Plectin
Human, Mouse, Rat, Guinea pig, Hamster
IHC - Paraffin, Western blot
Unconjugated
PLEC / Plectin Guinea pig Polyclonal Unconjugated Human, Fish IHC, WB C-Terminus No Primary
Anti-PLEC / Plectin Antibody (C-Terminus) LS-C193727
Guinea pig Polyclonal to Human PLEC / Plectin
Human, Fish
IHC, Western blot
Unconjugated
PLEC / Plectin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, ELISA No Primary
Anti-PLEC / Plectin Antibody LS-C406686
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human PLEC / Plectin
Human, Mouse, Rat
IHC, ELISA
Unconjugated
PLEC / Plectin Mouse IgG1 Monoclonal 10F6 Unconjugated Human, Mouse, Rat IHC-Fr, WB No Primary
Anti-PLEC / Plectin Antibody (clone 10F6) LS-C58284
Mouse Monoclonal [clone 10F6] (IgG1) to Human PLEC / Plectin
Human, Mouse, Rat
IHC - Frozen, Western blot
Unconjugated
PLEC / Plectin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC-P, WB No Primary
Anti-PLEC / Plectin Antibody LS-C490110
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image
Rabbit Polyclonal (IgG) to Human PLEC / Plectin
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
PLEC / Plectin Mouse IgG1 Monoclonal Unconjugated Rat IHC-Fr, ICC, IF, WB, ELISA Internal No Primary
Anti-PLEC / Plectin Antibody (Internal) LS-C91933
Mouse Monoclonal (IgG1) to Rat PLEC / Plectin
Rat
IHC - Frozen, ICC, Immunofluorescence, Western blot, ELISA
Unconjugated
PLEC / Plectin Mouse IgG1 Monoclonal Biotin Conjugated Human, Mouse, Rat IHC-Fr, WB No Primary
Anti-PLEC / Plectin Antibody (Biotin) LS-C38260
Mouse Monoclonal (IgG1) to Human PLEC / Plectin
Human, Mouse, Rat
IHC - Frozen, Western blot
Biotin Conjugated
PLEC / Plectin Mouse IgG2a,k Monoclonal 4D12 Unconjugated Human WB, ELISA No Primary
Anti-PLEC / Plectin Antibody (clone 4D12) LS-C197921
Enzyme-Linked Immunosorbent Assay Image
Mouse Monoclonal [clone 4D12] (IgG2a,k) to Human PLEC / Plectin
Human
Western blot, ELISA
Unconjugated
PLEC / Plectin Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa175-400 No Primary
Anti-PLEC / Plectin Antibody (aa175-400) LS-C373007
Western blot Image
Rabbit Polyclonal (IgG) to Human PLEC / Plectin
Human
Western blot, ELISA
Unconjugated
PLEC / Plectin Guinea pig Polyclonal Unconjugated Human aa4367-4684 No Primary
Anti-PLEC / Plectin Antibody (aa4367-4684) LS-C86201
Guinea pig Polyclonal to Human PLEC / Plectin
Human
Unconjugated
Type Target Reactivity Sample Type
Sandwich PLEC / Plectin Human Tissue Homogenates
Human PLEC / Plectin ELISA Kit (Sandwich ELISA) - LS-F8234
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Human
1.56-100 ng/ml
Colorimetric - 450nm
Tissue Homogenates
Sandwich (Custom) PLEC / Plectin Human
Human PLEC / Plectin ELISA Kit (Sandwich ELISA) (Custom) - LS-F17858
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Human
Sandwich (Custom) PLEC / Plectin Rat
Rat PLEC / Plectin ELISA Kit (Sandwich ELISA) (Custom) - LS-F17859
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Rat
Type Target Tag Species Source Purified Biological Activity Known Endotoxin Level Animal-Free
Recombinant PLEC / Plectin His, N-Terminal Human E. coli
Human PLEC / Plectin Recombinant (His, N-Terminal) Protein - LS-G25076
E. coli Expression System
His, N-Terminal
Unpurified

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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