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Unfortunately, the antibody (ID:37767) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



PLEC / Plectin

plectin

Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or "plectin 1, intermediate filament binding 500kDa". These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used.

Gene Name: plectin
Synonyms: PLEC, EBSO, LGMD2Q, HD1, PCN, PLEC1b, Plectin, PLTN, Plectin1, EBS1, PLEC1, Plectin-1
Target Sequences: NM_000445 NP_000436.2 Q15149

Filtered By: None
Target
plec-plectin (15)
Reactivity
Human (15)
Mouse (8)
Rat (7)
Bovine (1)
Fish (1)
Guinea pig (1)
Hamster (1)
Xenopus (2)
Application
IHC (2)
IHC-Fr (5)
IHC-P (6)
WB (13)
ELISA (2)
ICC (2)
IP (1)
Host
rabbit (7)
mouse (4)
guinea pig (4)
Isotype
IgG (8)
IgG1 (3)
IgG2a,k (1)
Clonality
monoclonal mc (5)
polyclonal pc (10)
Clone
10F6 (1)
4D12 (1)
E398P (1)
Format
Biotin Conjugated (2)
FITC Conjugated (1)
Unconjugated (12)
Epitope
aa175-400 (3)
aa4367-4684 (3)
C-Terminus (2)
aa2644-2671 (1)
Publications
No (15)
Showing 1-15 out of 15 results
Anti-PLEC / Plectin Antibody (C-Terminus, clone E398P) IHC-plus™ LS-B8172

Rabbit Monoclonal [clone E398P] (IgG) to Human PLEC / Plectin
Mouse, Rat, Human
IHC-P IP WB
Unconjugated
Anti-PLEC / Plectin Antibody (clone 10F6) LS-C58284

Mouse Monoclonal [clone 10F6] (IgG1) to Human PLEC / Plectin
Mouse, Rat, Human
IHC-Fr WB
Unconjugated
Anti-PLEC / Plectin Antibody LS-C406686

Rabbit Polyclonal (IgG) to Human PLEC / Plectin
Mouse, Rat, Human
ELISA IHC
Unconjugated
Anti-PLEC / Plectin Antibody LS-C124382

Mouse Monoclonal (IgG1) to Human PLEC / Plectin
Mouse, Rat, Human
IHC-Fr IHC-P WB
Unconjugated
Anti-PLEC / Plectin Antibody (aa2644-2671) LS-C407651

Rabbit Polyclonal to Human PLEC / Plectin
Mouse, Guinea pig, Rat, Hamster, Human
IHC-P WB
Unconjugated
Anti-PLEC / Plectin Antibody LS-C490110

Rabbit Polyclonal (IgG) to Human PLEC / Plectin
Mouse, Rat, Human
IHC-P WB
Unconjugated
Anti-PLEC / Plectin Antibody (clone 4D12) LS-C197921

Mouse Monoclonal [clone 4D12] (IgG2a,k) to Human PLEC / Plectin
Human
ELISA WB
Unconjugated
Anti-PLEC / Plectin Antibody (C-Terminus) LS-C193727

Guinea pig Polyclonal to Human PLEC / Plectin
Fish, Human
IHC WB
Unconjugated
Anti-PLEC / Plectin Antibody (aa4367-4684) LS-C38257

Guinea pig Polyclonal (IgG) to Human PLEC / Plectin
Xenopus, Human
IHC-Fr IHC-P WB
Unconjugated
Anti-PLEC / Plectin Antibody (aa4367-4684) LS-C38258

Guinea pig Polyclonal (IgG) to Human PLEC / Plectin
Xenopus, Mouse, Bovine, Human
IHC-Fr IHC-P WB
Unconjugated
Anti-PLEC / Plectin Antibody (aa175-400, FITC) LS-C422623

Rabbit Polyclonal (IgG) to Human PLEC / Plectin
Human
ICC WB
FITC Conjugated
Anti-PLEC / Plectin Antibody (aa175-400, Biotin) LS-C422621

Rabbit Polyclonal (IgG) to Human PLEC / Plectin
Human
ICC WB
Biotin Conjugated
Anti-PLEC / Plectin Antibody (Biotin) LS-C38260

Mouse Monoclonal (IgG1) to Human PLEC / Plectin
Mouse, Rat, Human
IHC-Fr WB
Biotin Conjugated
Anti-PLEC / Plectin Antibody (aa175-400) LS-C373007

Rabbit Polyclonal (IgG) to Human PLEC / Plectin
Human
WB
Unconjugated
Anti-PLEC / Plectin Antibody (aa4367-4684) LS-C86201

Guinea pig Polyclonal to Human PLEC / Plectin
Human
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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