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PLCE1

phospholipase C, epsilon 1

PLCE1 is a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Name: phospholipase C, epsilon 1
Family/Subfamily: Phospholipase , not assigned-Phospholipase
Synonyms: PLCE1, KIAA1516, Phospholipase C, epsilon 1, PLC-epsilon-1, PPLC, Phospholipase C-epsilon-1, NPHS3, PLCE
Target Sequences: NM_016341 NP_057425.3 Q9P212

Publications (1)

1
Subtypes of Histopathologically Classical Aldosterone-Producing Adenomas Yield Various Transcriptomic Signaling and Outcomes. Vin-Cent Wu, Kang-Yung Peng, Yu-Ping Kuo, Hsuan Liu, Bertrand Chin-Ming Tan, Yen-Hung Lin, Tai-Shuan Lai, Yung-Ming Chen, Jeff S Chueh, TAIPAI. Hypertension. 2021 December;78:1791-1800. [Full Text Article] [PubMed:34657444] Related Antibodies: LS-C804166.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
PLCE1 (5)
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His-T7, N-terminus (2)
Myc-DDK (Flag) (3)
Human (2)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
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PLCE1 Protein - Purified recombinant protein PLCE1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
258.5 kDa
20 µg/$1,107
PLCE1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
259.2 kDa
20 µg/$215
PLCE1 Protein - Recombinant Phospholipase C Epsilon 1 (PLCe1) by SDS-PAGE
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E. coli
His-T7, N-terminus
31.0kDa
10 µg/$287; 50 µg/$482; 200 µg/$962; 100 µg/$770; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
PLCE1 Protein - Recombinant Phospholipase C Epsilon 1 (PLCe1) by SDS-PAGE
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E. coli
His-T7, N-terminus
31.0kDa
10 µg/$289; 50 µg/$492; 200 µg/$982; 100 µg/$785; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
PLCE1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
259.2 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).