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Shirley, MA 01464
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PLCD4
phospholipase C, delta 4
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca2+ mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
| Gene Name: | phospholipase C, delta 4 |
| Family/Subfamily: | Phospholipase , not assigned-Phospholipase |
| Synonyms: | PLCD4, PLC-delta-4, Phospholipase C, delta 4, Phospholipase C-delta-4, PLC delta4, HPLCD4 |
| Target Sequences: | U16655 AAC52346.1 Q62711 |
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