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PLCD1 is a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene Name: | phospholipase C, delta 1 |
Family/Subfamily: | Phospholipase , not assigned-Phospholipase |
Synonyms: | PLCD1, NDNC3, Phospholipase C-delta-1, Phospholipase C, delta 1, Phospholipase C-III, PLC-delta-1, PLC-III |
Target Sequences: | NM_006225 NP_006216.2 P51178 |
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