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PLAU / Urokinase / uPA

plasminogen activator, urokinase

PLAU / Urokinase / uPA is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: plasminogen activator, urokinase
Family/Subfamily: Protease , Serine S1
Synonyms: PLAU, BDPLT5, U-PA, U-plasminogen activator, URK, Urokinase, Plasminogen activator, urinary, QPD, UPA
Target Sequences: NM_002658 NP_002649.1 P00749

Publications (1)

1
Preclinical evaluation of [111 In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity. Christel Vangestel, David Thomae, Jeroen Van Soom, Johan Ides, Leonie Wyffels, Patrick Pauwels, Sigrid Stroobants, Pieter Van der Veken, Viktor Magdolen, Jurgen Joossens, Koen Augustyns, Steven Staelens. Contrast media & molecular imaging. 2016 November;11:448-458. [Full Text Article] [PubMed:27558262] Related Antibodies: LS-C150831.

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Products
ELISA Kits (42)
Custom (3)
Functional (3)
Sandwich (31)
Sandwich CLIA (5)
PLAU / Urokinase / uPA (42)
Human (12)
Mouse (8)
Rat (9)
Bovine (1)
Chicken (2)
Guinea pig (1)
Horse (1)
Monkey (2)
Pig (2)
Porcine (1)
Rabbit (2)
12 x 8-Well Microstrips (4)
96-Well Microplate (8)
96-Well Strip Plate (30)
No (42)
Cell Culture Media (2)
Cell Culture Supernatants (6)
Cell Lysates (3)
Plasma (36)
Serum (30)
Tissue Extracts (2)
Tissue Homogenates (12)
Urine (4)
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
93.75 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.025 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Media, Plasma, Serum, Tissue Extracts, Urine
1 Plate/$896
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$889
PLAU / Urokinase / uPA ELISA Kit
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Functional
96-Well Strip Plate
Mouse
0.025 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$896
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Microplate
Human
13.11 - 3200 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$840
PLAU / Urokinase / uPA ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
PLAU / Urokinase / uPA ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
PLAU / Urokinase / uPA ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
PLAU / Urokinase / uPA ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
PLAU / Urokinase / uPA ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Microplate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Microplate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Microplate
Rabbit
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Microplate
Chicken
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PLAU / Urokinase / uPA ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
PLAU / Urokinase / uPA ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
PLAU / Urokinase / uPA ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
2.74 - 2000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Tissue Homogenates
1 Plate/$968
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Strip Plate
Horse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PLAU / Urokinase / uPA ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PLAU / Urokinase / uPA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).