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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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order histories, retained contact details for faster checkout, review submissions, and special promotions.
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order histories, retained contact details for faster checkout, review submissions, and special promotions.
PLAT / TPA
plasminogen activator, tissue
PLAT / TPA is tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
| Gene Name: | plasminogen activator, tissue |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | PLAT, Plasminogen activator, Plasminogen activator, tissue, Tissue plasminogen activator, T-PA, T-plasminogen activator, TPA |
| Target Sequences: | NM_000930 NP_000921.1 P00750 |
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