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PLAP / Alkaline Phosphatase

Placental Alkaline Phosphatase

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.

Gene Name: Placental Alkaline Phosphatase
Synonyms: ALPP, ALP, Alkaline phosphomonoesterase, Glycerophosphatase, PALP, PLAP, PLAP-1, Alp1, Germ-cell alkaline phosphatase, Nagao isozyme, Regan isozyme
Target Sequences: NM_001632 NP_001623.3 P05187

Publications (4)

1
Fusion of Epstein-Barr virus with epithelial cells can be triggered by v5 in addition to v6 and v8, and integrin binding triggers a conformational change in glycoproteins gHgL. Chesnokova LS, Hutt-Fletcher LM. Journal of virology. 2011 85:13214-23. (Human) [Full Text Article] [PubMed:21957301] [PMC:PMC3233123] Related Antibodies: LS-C44264.
2
Duration of simulated microgravity affects the differentiation of mesenchymal stem cells. Xue L, Li Y, Chen J. Molecular medicine reports. 2017 15:3011-3018. (Flo; Human) [Full Text Article] [PubMed:28339035] [PMC:PMC5428749] Related Antibodies: LS-C44264.
3
alpha v beta 3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1. Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G. Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov;109:19792-7. [Full Text Article] [PubMed:23150579] [PMC:PMC3511702] Related Antibodies: LS-C44264.
4
alpha v beta 6- and alpha v beta 8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion. Gianni T, Salvioli S, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G. PLoS pathogens. 2013 Dec;9:e1003806. [Full Text Article] [PubMed:24367260] [PMC:PMC3868510] Related Antibodies: LS-C44264.
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Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
PLAP / Alkaline Phosphatase (10)
No (10)
10His, N-terminus (2)
6His, C-terminus (2)
GST (1)
His, N-Terminal (2)
Myc-DDK (Flag) (3)
Human (8)
Rat (1)
293T Cells (1)
Baculovirus (1)
E. coli (3)
HEK 293 Cells (2)
Human Cells (1)
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Purified (4)
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
53.7kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
PLAP / Alkaline Phosphatase Protein - Purified recombinant protein ALPP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
55.5 kDa
20 µg/$1,107
PLAP / Alkaline Phosphatase Protein
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E. coli
His, N-Terminal
56 kDa
10 µg/$265; 100 µg/$365; 50 µg/$315
PLAP / Alkaline Phosphatase Protein - Recombinant Alkaline Phosphatase, Placental By SDS-PAGE
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E. coli
His, N-Terminal
30.8 kDa
50 µg/$442; 10 µg/$281; 200 µg/$882; 1 mg/$1,989; 5 mg/$3,081; 2 mg/$2,176
PLAP / Alkaline Phosphatase Protein - 12.5% SDS-PAGE of human ALPP stained with Coomassie Blue
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Wheat Germ Extract
GST
84.4 kDa
10 µg/$479; 25 µg/$670
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Baculovirus
10His, N-terminus
100 µg/$1,067; 20 µg/$447; 1 mg/$1,988
PLAP / Alkaline Phosphatase Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus
41.9 kDa
1 mg/$1,486; 100 µg/$451; 20 µg/$339
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
53.7 kDa
10 µg/$344; 50 µg/$584
PLAP / Alkaline Phosphatase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
57.95 kDa
100 µg/$494
PLAP / Alkaline Phosphatase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
57.95 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).