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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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PLA2G5
phospholipase A2, group V
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.
| Gene Name: | phospholipase A2, group V |
| Family/Subfamily: | Phospholipase , not assigned-Phospholipase |
| Synonyms: | PLA2G5, GV-PLA2, HVPLA(2), FRFB, Phospholipase A2, group V, PLA2-10, Group V phospholipase A2 |
| Target Sequences: | NM_000929 NP_000920.1 P39877 |
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