PKN1

protein kinase N1

PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

PKN1 (7)

Publications

No (7)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human PKN1 Protein (Recombinant 6His, N-terminus) - LS-G137451

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

34.5 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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PKN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117789

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

103.8 kDa

Price:

100 µg/$494

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Human PKN1 Protein (Recombinant GST) (Full Length) - LS-G29906

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

130.3 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PKN1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67840

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

103.8 kDa

Price:

20 µg/$1,107

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Human PKN1 Protein (Recombinant GST, N-terminus) (aa462-615) - LS-G59732

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PKN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80826

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

103.8 kDa

Price:

20 µg/$150

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Human PKN1 Protein (Recombinant His-T7) (aa615-874) - LS-G12248

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.9 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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