PKN1

protein kinase N1

PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.

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Products

ELISA Kits (6)

Type

Competitive EIA (1)

Sandwich (5)

Target

PKN1 (6)

Reactivity

Human (2)

Mouse (2)

Rat (1)

Monkey (1)

Format

96-Well Strip Plate (6)

Publications

No (6)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (2)

Plasma (4)

Serum (4)

Tissue Homogenates (2)

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Monkey PKN1 (Sandwich ELISA) ELISA Kit - LS-F47418

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Human PKN1 (Sandwich ELISA) ELISA Kit - LS-F37922

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse PKN1 (Competitive EIA) ELISA Kit - LS-F38904

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

123.5 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$818

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Mouse PKN1 (Sandwich ELISA) ELISA Kit - LS-F38401

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Rat PKN1 (Sandwich ELISA) ELISA Kit - LS-F38690

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human PKN1 (Sandwich ELISA) ELISA Kit - LS-F9452

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$764

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