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PKMYT1

protein kinase, membrane associated tyrosine/threonine 1

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Gene Name: protein kinase, membrane associated tyrosine/threonine 1
Family/Subfamily: Protein Kinase , wee1/mik1
Synonyms: PKMYT1, Myt1 kinase
Target Sequences: NM_004203 NP_004194.3 Q99640

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PKMYT1 ELISA Kit
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).