PKD2 / Polycystin 2

polycystic kidney disease 2 (autosomal dominant)

Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.

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Proteins (1)

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Recombinant (1)

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PKD2 / Polycystin 2 (1)

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GST, N-terminus (1)

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Human (1)

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Wheat Germ Extract (1)

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Human PKD2 / Polycystin 2 Protein (Recombinant GST, N-terminus) (aa261-360) - LS-G59621

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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