PIWIL1 / PIWI

piwi-like RNA-mediated gene silencing 1

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

PIWIL1 / PIWI (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human PIWIL1 / PIWI Protein (Recombinant GST, N-terminus) (aa431-541) - LS-G61057

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PIWIL1 / PIWI Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85254

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.4 kDa

Price:

20 µg/$150

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PIWIL1 / PIWI Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100382

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.4 kDa

Price:

100 µg/$494

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