PITX3

paired-like homeodomain 3

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

PITX3 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus + His, C-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Mouse (2)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Yeast (1)

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Human PITX3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89327

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.7 kDa

Price:

20 µg/$150

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PITX3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116253

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.7 kDa

Price:

100 µg/$494

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Human PITX3 Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G144830

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

57.7 kDa

Price:

50 µg/$419

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Mouse PITX3 Protein (Recombinant GST) (Full Length) - LS-G21053

Source:

E. coli

Tag:

GST

Molecular Weight:

59.1 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Mouse PITX3 Protein (Recombinant His) (Full Length) - LS-G23074

Source:

Yeast

Tag:

His

Molecular Weight:

33.7 kD

Price:

1 mg/$1,683; 100 µg/$499; 20 µg/$364

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