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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PIP5K1A

phosphatidylinositol-4-phosphate 5-kinase, type I, alpha

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.

Gene Name: phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Family/Subfamily: Non-Protein Kinase , not assigned-Non-Protein Kinase
Synonyms: PIP5K1A, PIP5KIalpha, PtdIns(4)P-5-kinase 1 alpha, PIP5K1-alpha
Target Sequences: NM_003557 NP_003548.1 Q99755

Filtered By: None
Target
PIP5K1A (24)
Reactivity
Human (24)
Mouse (6)
Rat (6)
Bat (4)
Bovine (4)
Chicken (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (4)
Hamster (4)
Horse (4)
Monkey (4)
Orangutan (3)
Pig (4)
Rabbit (4)
Xenopus (4)
Zebrafish (4)
Application
IHC (7)
IHC-P (2)
WB (24)
ELISA (12)
IF (3)
Host
rabbit (24)
Isotype
IgG (13)
Clonality
polyclonal pc (24)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (12)
Epitope
aa19-50 (8)
Internal (5)
aa38-87 (4)
Publications
No (24)
Showing 1-24 of 24 results

PIP5K1A Antibody (Internal) IHC-plus™ LS-B10813
Rabbit Polyclonal to Human PIP5K1A
Human
ELISA IHC IHC-P WB
Unconjugated
50µg  $425.00
Anti-PIP5K1A antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-PIP5K1A antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

PIP5K1A Antibody LS-C755322
Rabbit Polyclonal (IgG) to Human PIP5K1A
Human
ELISA IF IHC WB
Unconjugated
100µg  $335.00

PIP5K1A Antibody LS-C676262
Rabbit Polyclonal (IgG) to Human PIP5K1A
Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $235.00; 100µl  $285.00
Immunohistochemistry of paraffin-embedded human heart tissue at dilution 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue at dilution 1:100
Immunohistochemistry of paraffin-embedded human heart tissue at dilution 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue at dilution 1:100

PIP5K1A Antibody LS-C409488
Rabbit Polyclonal (IgG) to Human PIP5K1A
Mouse, Human
IF IHC WB
Unconjugated
50µl  $255.00; 100µl  $315.00; 200µl  $425.00
Immunofluorescence analysis of A549 cells.
Immunofluorescence analysis of A549 cells.
Immunofluorescence analysis of A549 cells.
Immunofluorescence analysis of A549 cells.

PIP5K1A Antibody LS-C404646
Rabbit Polyclonal (IgG) to Human PIP5K1A
Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human thyroid cancer using PIP5K1A Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human brain using PIP5K1A Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human thyroid cancer using PIP5K1A Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human brain using PIP5K1A Polyclonal Antibody at dilution of 1:30.

PIP5K1A Antibody LS-C748426
Rabbit Polyclonal (IgG) to Human PIP5K1A
Rat, Human
IF IHC WB
Unconjugated
50µl  $235.00
Immunofluorescence analysis of A549 cells using PIP5K1A antibody.
Western blot analysis of extracts of various cell lines, using PIP5K1A antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
Immunofluorescence analysis of A549 cells using PIP5K1A antibody.
Western blot analysis of extracts of various cell lines, using PIP5K1A antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.

PIP5K1A Antibody LS-C401366
Rabbit Polyclonal (IgG) to Human PIP5K1A
Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human colon cancer using PIP5K1A Polyclonal Antibody at dilution of 1:20.
Western blot analysis of HeLa, A431 and 293T cell, using PIP5K1A Polyclonal Antibody at dilution of 1:260.
Immunohistochemistry of Human colon cancer using PIP5K1A Polyclonal Antibody at dilution of 1:20.
Western blot analysis of HeLa, A431 and 293T cell, using PIP5K1A Polyclonal Antibody at dilution of 1:260.

PIP5K1A Antibody (aa19-50) LS-C330580
Rabbit Polyclonal (IgG) to Human PIP5K1A
Human
ELISA WB
Unconjugated
200µl 0.25mg/ml  $530.00

PIP5K1A Antibody (aa19-50, Biotin) LS-C220328
Rabbit Polyclonal (IgG) to Human PIP5K1A
Human
ELISA WB
Biotin Conjugated
200µl  $680.00

PIP5K1A Antibody (aa19-50, FITC) LS-C220329
Rabbit Polyclonal (IgG) to Human PIP5K1A
Human
ELISA WB
FITC Conjugated
200µl  $680.00

PIP5K1A Antibody (aa19-50, Azide-free, HRP) LS-C220330
Rabbit Polyclonal (IgG) to Human PIP5K1A
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

PIP5K1A Antibody (aa19-50, PE) LS-C220331
Rabbit Polyclonal (IgG) to Human PIP5K1A
Human
ELISA WB
PE Conjugated
200µl  $680.00

PIP5K1A Antibody (aa19-50, APC) LS-C220327
Rabbit Polyclonal (IgG) to Human PIP5K1A
Human
ELISA WB
APC Conjugated
200µl  $680.00

PIP5K1A Antibody (aa19-50, AP) LS-C220322
Rabbit Polyclonal (IgG) to Human PIP5K1A
Human
ELISA WB
AP Conjugated
200µl  $680.00

PIP5K1A Antibody (aa38-87) LS-C201758
Rabbit Polyclonal to Mouse PIP5K1A
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Hamster, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
WB
Unconjugated
50µg  $365.00
Western blot of Mouse Lung. Pip5k1a antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of Mouse Lung. Pip5k1a antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PIP5K1A Antibody (aa38-87, HRP) LS-C468148
Rabbit Polyclonal to Mouse PIP5K1A
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Western blot of Mouse Lung. Pip5k1a antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of Mouse Lung. Pip5k1a antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PIP5K1A Antibody (aa38-87, Biotin) LS-C468147
Rabbit Polyclonal to Mouse PIP5K1A
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Western blot of Mouse Lung. Pip5k1a antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of Mouse Lung. Pip5k1a antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PIP5K1A Antibody (aa38-87, FITC) LS-C468146
Rabbit Polyclonal to Mouse PIP5K1A
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
WB
FITC Conjugated
100µl 1mg/ml  $385.00
Western blot of Mouse Lung. Pip5k1a antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of Mouse Lung. Pip5k1a antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PIP5K1A Antibody (Internal) LS-C345578
Rabbit Polyclonal to Human PIP5K1A
Human
WB
Unconjugated
50µg  $365.00
Western blot of PIP5K1A Antibody with human MCF7 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of PIP5K1A Antibody with human MCF7 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PIP5K1A Antibody (Internal, HRP) LS-C468145
Rabbit Polyclonal to Human PIP5K1A
Human
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Western blot of PIP5K1A Antibody with human MCF7 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of PIP5K1A Antibody with human MCF7 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PIP5K1A Antibody (Internal, Biotin) LS-C468143
Rabbit Polyclonal to Human PIP5K1A
Human
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Western blot of PIP5K1A Antibody with human MCF7 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of PIP5K1A Antibody with human MCF7 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PIP5K1A Antibody (Internal, FITC) LS-C468144
Rabbit Polyclonal to Human PIP5K1A
Human
WB
FITC Conjugated
100µl 1mg/ml  $385.00
Western blot of PIP5K1A Antibody with human MCF7 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of PIP5K1A Antibody with human MCF7 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PIP5K1A Antibody LS-C482926
Rabbit Polyclonal to Human PIP5K1A
Mouse, Rat, Human
WB
Unconjugated
50µl 1mg/ml  $255.00; 100µl 1mg/ml  $295.00; 200µl 1mg/ml  $375.00
Western blot analysis of PIP5K1 alpha expression in HeLa (A) whole cell lysates.
Western blot analysis of PIP5K1 alpha expression in HeLa (A) whole cell lysates.

PIP5K1A Antibody (aa19-50) LS-C101112
Rabbit Polyclonal to Human PIP5K1A
Human
WB
Unconjugated
400µl  $305.00
Western blot of PIP5K1A (arrow) using rabbit polyclonal hPIP5K1A-R34. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PIP5K1A gene.
Western blot of anti-PIP5K1A antibody in HeLa cell lysate. PIP5K1A (arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Western blot of PIP5K1A (arrow) using rabbit polyclonal hPIP5K1A-R34. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PIP5K1A gene.
Western blot of anti-PIP5K1A antibody in HeLa cell lysate. PIP5K1A (arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Showing 1-24 of 24 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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