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Unfortunately, the antibody (ID:106032) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



PINK1

PTEN induced putative kinase 1

Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582).

Gene Name: PTEN induced putative kinase 1
Family/Subfamily: Protein Kinase , NFK
Synonyms: PINK1, BRPK, PTEN induced putative kinase 1, PARK6, PTEN-induced putative kinase, Protein kinase BRPK
Target Sequences: NM_032409 NP_115785.1 Q9BXM7

Publications (21)

1
Evaluation of the effectiveness and safety of etodolac in prolonged treatment of active osteoarthritis. Puccetti L, Ciompi ML. International journal of clinical pharmacology research. 1991 11:143-58. [PubMed:1839736]
2
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. Exner N, Treske B, Paquet D, Holmstrm K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 27:12413-8. (WB) [PubMed:17989306]
3
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. Weihofen A, Ostaszewski B, Minami Y, Selkoe DJ. Human molecular genetics. 2008 17:602-16. [PubMed:18003639]
4
Characterization of PINK1 processing, stability, and subcellular localization. Lin W, Kang UJ. Journal of neurochemistry. 2008 106:464-74. (WB; Human) [PubMed:18397367]
5
The kinase domain of mitochondrial PINK1 faces the cytoplasm. Zhou C, Huang Y, Shao Y, May J, Prou D, Perier C, Dauer W, Schon EA, Przedborski S. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:12022-7. [PubMed:18687899] [PMC:PMC2575334]
6
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease. Liu W, Vives-Bauza C, Acn-Perz- R, Yamamoto A, Tan Y, Li Y, Magran J, Stavarache MA, Shaffer S, Chang S, Kaplitt MG, Huang XY, Beal MF, Manfredi G, Li C. PloS one. 2009 4:e4597. [PubMed:19242547] [PMC:PMC2644779]
7
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lmmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, Winklhofer KF. The Journal of biological chemistry. 2009 284:22938-51. [PubMed:19546216] [PMC:PMC2755701]
8
Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. Cui M, Tang X, Christian WV, Yoon Y, Tieu K. The Journal of biological chemistry. 2010 285:11740-52. [PubMed:20164189] [PMC:PMC2857048]
9
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park. Human molecular genetics. 2010 19:3734-46. (WB; Mouse) [PubMed:20639397]
10
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Chen S, Shao F. Science (New York, N.Y.). 2010 329:1215-8. [PubMed:20688984] [PMC:PMC3031172]
11
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Geisler S, Holmstrm KM, Treis A, Skujat D, Weber SS, Fiesel FC, Kahle PJ, Springer W. Autophagy. 2010 6:871-8. (WB; Human) [PubMed:20798600]
12
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. Meissner C, Lorenz H, Weihofen A, Selkoe DJ, Lemberg MK. Journal of neurochemistry. 2011 117:856-67. [PubMed:21426348]
13
Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease. Dagda RK, Gusdon AM, Pien I, Strack S, Green S, Li C, Van Houten B, Cherra SJ, Chu CT. Cell death and differentiation. 2011 18:1914-23. [PubMed:21637291] [PMC:PMC3177020]
14
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy. Mitsuhashi S, Hatakeyama H, Karahashi M, Koumura T, Nonaka I, Hayashi YK, Noguchi S, Sher RB, Nakagawa Y, Manfredi G, Goto Y, Cox GA, Nishino I. Human molecular genetics. 2011 20:3841-51. (ICC, IHC; Mouse) [PubMed:21750112] [PMC:PMC3168292]
15
Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease. Yasuda T, Hayakawa H, Nihira T, Ren YR, Nakata Y, Nagai M, Hattori N, Miyake K, Takada M, Shimada T, Mizuno Y, Mochizuki H. Journal of neuropathology and experimental neurology. 2011 70:686-97. (WB; Mouse) [PubMed:21760537]
16
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM. Open biology. 2012 2:120080. (WB; Human) [PubMed:22724072] [PMC:PMC3376738]
17
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Okatsu K, Oka T, Iguchi M, Imamura K, Kosako H, Tani N, Kimura M, Go E, Koyano F, Funayama M, Shiba-Fukushima K, Sato S, Shimizu H, Fukunaga Y, Taniguchi H, Komatsu M, Hattori N, Mihara K, Tanaka K, Matsuda N. Nature communications. 2012 3:1016. (ICC, WB; Mouse, Human) [PubMed:22910362] [PMC:PMC3432468]
18
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5. Sekine S, Kanamaru Y, Koike M, Nishihara A, Okada M, Kinoshita H, Kamiyama M, Maruyama J, Uchiyama Y, Ishihara N, Takeda K, Ichijo H. The Journal of biological chemistry. 2012 287:34635-45. [PubMed:22915595] [PMC:PMC3464569]
19
The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease. Wood-Kaczmar A, Deas E, Wood NW, Abramov AY. Advances in experimental medicine and biology. 2013 961:241-9. (ICC; Human) [PubMed:23224884]
20
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Shiba-Fukushima K, Imai Y, Yoshida S, Ishihama Y, Kanao T, Sato S, Hattori N. Scientific reports. 2012 2:1002. (WB; Mouse) [PubMed:23256036] [PMC:PMC3525937]
21
Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila. Song S, Jang S, Park J, Bang S, Choi S, Kwon KY, Zhuang X, Kim E, Chung J. The Journal of biological chemistry. 2013 288:5660-72. (ICC, WB; Human) [PubMed:23303188] [PMC:PMC3581423]
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Filtered By: None
Target
pink1 (72)
Reactivity
Human (59)
Mouse (38)
Rat (14)
Bat (1)
Bovine (1)
Chimpanzee (3)
Dog (1)
Guinea pig (4)
Monkey (6)
Rabbit (4)
Application
IHC (20)
IHC-P (13)
WB (61)
ELISA (32)
ICC (5)
IF (6)
Host
rabbit (55)
mouse (16)
goat (1)
Isotype
IgG (36)
IgG1 (1)
IgG1,k (8)
Clonality
monoclonal mc (16)
polyclonal pc (56)
Clone
38CT18.7 (1)
38CT20.8.5 (7)
S4-15 (1)
Format
AP Conjugated (4)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (10)
DY488 Conjugated (2)
DY550 Conjugated (2)
DY650 Conjugated (2)
FITC Conjugated (8)
HRP Conjugated (6)
PE Conjugated (4)
Unconjugated (30)
Epitope
N-Terminus (7)
aa118-146 (5)
aa350-500 (5)
aa493-526 (5)
aa91-140 (4)
aa262-507 (3)
aa310-566 (3)
C-Terminus (2)
aa258-274 (2)
aa1-18 (1)
aa1-50 (1)
aa112-496 (1)
aa117-146 (1)
aa118-147 (1)
aa175-250 (1)
aa456-470 (1)
aa484-504 (1)
aa502-532 (1)
Publications
No (72)
Showing 1-25 out of 72 results
Anti-PINK1 Antibody (aa484-504) IHC-plus™ LS-B1502

Rabbit Polyclonal (IgG) to Human PINK1
Human, Monkey
IHC-P WB
Unconjugated
Anti-PINK1 Antibody (aa350-500) IHC-plus™ LS-B14185

Rabbit Polyclonal to Human PINK1
Mouse, Human
IHC-P
Unconjugated
Anti-PINK1 Antibody (aa350-500, Biotin) LS-C143547

Rabbit Polyclonal to Human PINK1
Mouse, Human
ICC IF IHC-P
Biotin Conjugated
Anti-PINK1 Antibody (aa350-500, DY550) LS-C143551

Rabbit Polyclonal to Human PINK1
Mouse, Human
ICC IF IHC-P
DY550 Conjugated
Anti-PINK1 Antibody (aa350-500, DY650) LS-C143548

Rabbit Polyclonal to Human PINK1
Mouse, Human
ICC IF IHC-P
DY650 Conjugated
Anti-PINK1 Antibody (aa350-500, DY488) LS-C143549

Rabbit Polyclonal to Human PINK1
Mouse, Human
ICC IF IHC-P
DY488 Conjugated
Anti-PINK1 Antibody LS-C346251

Rabbit Polyclonal (IgG) to Human PINK1
Mouse, Rat, Human
IF IHC WB
Unconjugated
Anti-PINK1 Antibody (C-Terminus) LS-C47093

Rabbit Polyclonal to Mouse PINK1
Mouse, Rat
ELISA WB
Unconjugated
Anti-PINK1 Antibody (N-Terminus) IHC-plus™ LS-B12148

Rabbit Polyclonal to Human PINK1
Mouse, Rat, Human
ELISA IHC-P WB
Unconjugated
Anti-PINK1 Antibody (aa493-526) LS-C163368

Rabbit Polyclonal to Human PINK1
Mouse, Human
WB
Unconjugated
Anti-PINK1 Antibody (aa91-140) IHC-plus™ LS-B12030

Rabbit Polyclonal to Human PINK1
Rabbit, Guinea pig, Rat, Human, Monkey
IHC-P WB
Unconjugated
Anti-PINK1 Antibody (aa112-496, clone S4-15) LS-C209547

Mouse Monoclonal [clone S4-15] (IgG1) to Human PINK1
Mouse, Rat, Human
ICC IHC WB
Unconjugated
Anti-PINK1 Antibody LS-C412748

Rabbit Polyclonal to Human PINK1
Mouse, Rat, Human
IF IHC WB
Unconjugated
Anti-PINK1 Antibody (clone 38CT20.8.5) LS-C319196

Mouse Monoclonal [clone 38CT20.8.5] (IgG) to Human PINK1
Human
ELISA IHC WB
Unconjugated
Anti-PINK1 Antibody (clone 38CT20.8.5, Biotin) LS-C250386

Mouse Monoclonal [clone 38CT20.8.5] (IgG) to Human PINK1
Human
ELISA IHC WB
Biotin Conjugated
Anti-PINK1 Antibody (clone 38CT20.8.5, FITC) LS-C250387

Mouse Monoclonal [clone 38CT20.8.5] (IgG) to Human PINK1
Human
ELISA IHC WB
FITC Conjugated
Anti-PINK1 Antibody (clone 38CT20.8.5, AP) LS-C250384

Mouse Monoclonal [clone 38CT20.8.5] (IgG) to Human PINK1
Human
ELISA IHC WB
AP Conjugated
Anti-PINK1 Antibody (clone 38CT20.8.5, Azide-free, HRP) LS-C250388

Mouse Monoclonal [clone 38CT20.8.5] (IgG) to Human PINK1
Human
ELISA IHC WB
HRP Conjugated, Azide-free
Anti-PINK1 Antibody (clone 38CT20.8.5, APC) LS-C250385

Mouse Monoclonal [clone 38CT20.8.5] (IgG) to Human PINK1
Human
ELISA IHC WB
APC Conjugated
Anti-PINK1 Antibody (clone 38CT20.8.5, PE) LS-C250391

Mouse Monoclonal [clone 38CT20.8.5] (IgG) to Human PINK1
Human
ELISA IHC WB
PE Conjugated
Anti-PINK1 Antibody (aa258-274) LS-C40756

Rabbit Polyclonal (IgG) to Human PINK1
Human
ELISA IHC WB
Unconjugated
Anti-PINK1 Antibody LS-C124456

Mouse Monoclonal (IgG1,k) to Human PINK1
Human
IHC WB
Unconjugated
Anti-PINK1 Antibody (aa118-147) LS-C99189

Rabbit Polyclonal to Human PINK1
Human
IHC-P WB
Unconjugated
Anti-PINK1 Antibody (aa117-146) LS-C324058

Rabbit Polyclonal (IgG) to Mouse PINK1
Mouse
ELISA WB
Unconjugated
Anti-PINK1 Antibody (aa258-274) LS-C9809

Rabbit Polyclonal (IgG) to Human PINK1
Human
IHC WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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