PIM2 / Pim-2

pim-2 oncogene

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Isoform 1 is less active in this respect. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

PIM2 / Pim-2 (8)

Publications

No (8)

Tag

GST (1)

His (1)

His-T7 (3)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human PIM2 / Pim-2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68275

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34 kDa

Price:

20 µg/$1,107

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Human PIM2 / Pim-2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81811

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34 kDa

Price:

20 µg/$150

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Mouse PIM2 / Pim-2 Protein (Recombinant His-T7) (aa98-319) - LS-G16299

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.6 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Rat PIM2 / Pim-2 Protein (Recombinant His-T7) (aa34-292) - LS-G16301

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human PIM2 / Pim-2 Protein (Recombinant GST) (Full Length) - LS-G32471

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

60.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PIM2 / Pim-2 Protein (Recombinant His-T7) (aa82-291) - LS-G26237

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.4 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Human PIM2 / Pim-2 Protein (Recombinant His) - LS-G2915

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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PIM2 / Pim-2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115019

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34 kDa

Price:

100 µg/$494

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