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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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PIM1 / Pim-1

pim-1 oncogene

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.

Gene Name: pim-1 oncogene
Family/Subfamily: Protein Kinase , PIM
Synonyms: PIM1, Pim-1 kinase 44 kDa isoform, Proviral integration site 1, Oncogene PIM1, PIM, Pim-1, Pim-1 oncogene
Target Sequences: NM_002648 NP_002639.1 P11309

Publications (1)

1
PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas. Baron BW, Anastasi J, Hyjek EM, Bies J, Reddy PL, Dong J, Joseph L, Thirman MJ, Wroblewski K, Wolff L, Baron JM. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:5735-9. [PubMed:22451912] [PMC:PMC3326467] Related Antibodies: LS-C99723.

Viewing 1-25 of 78 items
PIM1 / Pim-1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
Rabbit Polyclonal to Human PIM1 / Pim-1
IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
PIM1 / Pim-1 Antibody - Anti-PIM1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal [clone 6A2] (IgG1,k) to Human PIM1 / Pim-1
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50µg   $495.00
PIM1 / Pim-1 Antibody - Anti-PIM1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal [clone 2C9] (IgG2a,k) to Human PIM1 / Pim-1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
PIM1 / Pim-1 Antibody - Anti-PIM1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal [clone X1] (IgG2a,k) to Human PIM1 / Pim-1
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50µg   $495.00
PIM1 / Pim-1 Antibody - Anti-PIM1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal [clone 3F5] (IgG2a,l) to Human PIM1 / Pim-1
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50µg   $495.00
PIM1 / Pim-1 Antibody - Formalin-fixed and paraffin-embedded human prostate carcinoma tissue reacted with PIM1 antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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(1) Publication(s)
Rabbit Polyclonal to Human PIM1 / Pim-1
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
PIM1 / Pim-1 Antibody - Immunohistochemistry of paraffin-embedded human spleen using PIM1 antibodyat dilution of 1:100 (40x lens).
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Rabbit Monoclonal to Human PIM1 / Pim-1
Mouse, Human
IF, IHC, WB
Unconjugated
50µl   $295.00; 100µl   $385.00; 200µl   $560.00
PIM1 / Pim-1 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Rabbit Polyclonal to Human PIM1 / Pim-1
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
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Rabbit Polyclonal (IgG) to Human PIM1 / Pim-1
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
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Rabbit Polyclonal (IgG) to Human PIM1 / Pim-1
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human PIM1 / Pim-1
Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human PIM1 / Pim-1
Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human PIM1 / Pim-1
Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human PIM1 / Pim-1
Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human PIM1 / Pim-1
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
PIM1 / Pim-1 Antibody - Western blot analysis of lysates from Jurkat cells, using Pim-1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Rabbit Polyclonal (IgG) to Human PIM1 / Pim-1
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
PIM1 / Pim-1 Antibody - Mouse Pim1 Antibody western blot of Jurkat cell line lysates (35 ug/lane). The Pim1 antibody detected the Pim1 protein (arrow).
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Rabbit Polyclonal to Mouse PIM1 / Pim-1
Mouse, Human
WB
Unconjugated
400µl   $325.00
PIM1 / Pim-1 Antibody - Western Blot; Sample: Recombinant protein.
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Rabbit Polyclonal to Mouse PIM1 / Pim-1
Mouse
WB
Unconjugated
20µl   0.5mg/ml   $205.00; 100µl   0.5mg/ml   $265.00; 200µl   0.5mg/ml   $305.00; 1ml   0.5mg/ml   $545.00
PIM1 / Pim-1 Antibody - PIM1 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human PIM1 / Pim-1
Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $385.00
PIM1 / Pim-1 Antibody - Western blot of recombinant PIM1 / Pim-1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human PIM1 / Pim-1
Mouse, Rat, Human
WB
Unconjugated
20µl   0.5mg/ml   $205.00; 100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $305.00; 1ml   0.5mg/ml   $530.00
PIM1 / Pim-1 Antibody - Western blot of recombinant PIM1 / Pim-1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human PIM1 / Pim-1
Mouse, Rat, Human
WB
APC Conjugated
100µl   0.1mg/ml   $275.00; 200µl   0.1mg/ml   $315.00; 1ml   0.1mg/ml   $590.00
PIM1 / Pim-1 Antibody - Immunohistochemistry of paraffin-embedded human prostate cancer at dilution of 1:100
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Rabbit Polyclonal (IgG) to Human PIM1 / Pim-1
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50µg   $285.00; 100µg   $385.00
PIM1 / Pim-1 Antibody
Select
Rabbit Polyclonal (IgG) to Human PIM1 / Pim-1
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal to Human PIM1 / Pim-1
Human
ICC, IF, WB
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
PIM1 / Pim-1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human PIM1 / Pim-1
IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00

Viewing 1-25 of 78 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).