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PILRB
paired immunoglobin-like type 2 receptor beta
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function.
| Gene Name: | paired immunoglobin-like type 2 receptor beta |
| Synonyms: | PILRB, Activating receptor PILR-beta, Activating receptor PILRbeta, Cell surface receptor FDFACT, Cell surface receptor FDFACT1, Cell surface receptor FDFACT2, FDFACT2, FDFACT1, FDFACT |
| Target Sequences: | NM_013440 NP_038468.3 Q9UKJ0 |
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