PILRA

paired immunoglobin-like type 2 receptor alpha

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

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ELISA Kits (1)

Type

Sandwich (1)

Target

PILRA (1)

Reactivity

Human (1)

Format

96-Well Microplate (1)

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Sample Type

Cell Culture Supernatants (1)

Plasma (1)

Serum (1)

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Human PILRA (Sandwich ELISA) ELISA Kit - LS-F50519

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

6.14 - 1500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$672

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